Hemorrhoids are masses or clumps ("cushions") of tissue within the anal canal that contain blood vessels. Although most people think hemorrhoids are abnormal, they are present in everyone. It is only when the hemorrhoidal cushions enlarge that hemorrhoids become susceptible to trauma from passing st...
bacilliferous granulomas) contain numerous CD31-positive micro-vessels not found in patients with paucibacil- liary tuberculoid leprosy53. Anti-angiogenic agents may be used as adjunctive host-directed therapies in TB as they are for leprosy. VEGF antagonists are already used for the treatment of...
Blood Glucose Self-MonitoringDiagnostic Tests, RoutineTreatment OutcomeTime FactorsCost-Benefit AnalysisPoint-of-Care SystemsThe present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic ...
The shear stress resulting from blood flow modulates the functions of endothelial cells (ECs), including the regulation of genes encoding for vasoactive substances, growth factors, adhesion molecules, chemoattractants, coagulation factors, and proto-oncogenes.1, 2 The shear modulation of these genes ...
Two further major cell types of the human heart include ECs, which form the inner lining of heart blood vessels and SMCs, the major constituents of the heart vasculature. ECs contain numerous storage granules filled with von Willebrand factor (VWF), which is involved in hemostasis. VWF was one...
NPY and its receptors are associated with numerous human autoimmune diseases To further explore the role of NPY in the human inflammatory response, we examined the effect of exogenous NPY on cytokine gene expression in cultured human peripheral blood lymphocytes during LPS treatment. As shown in Figu...
‘Huang Di Nei Jin’ also contains numerous discussions on brain disorders [3,4]. However, in the past, due to the use of traditional administration methods, Chinese medicine could not exert its desired therapeutic effect. At the same time, the existence of the blood–brain barrier (BBB) ...
[154,155,156]. Four main strategies are considered to develop antiangiogenic agents: inhibiting endogenous factors promoting angiogenesis, identifying and applying natural angiogenesis inhibitors, inhibiting the molecules that promote the invasion of the surrounding tissue through tumour blood vessels, and ...
Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages and mast cells which are important regulator
Numerous additional substances contained in foods or supplements, in addition to these nutraceuticals, have also been proven to have potential anticancer benefits104. These include sulforaphane, a substance found in cruciferous vegetables, which can activate Nrf2, a transcription factor that controls antiox...