The blood-brain barrier (BBB) is the anatomophysiological unit that interfaces between the blood and the brain. It is composed of brain vascular endothelial cells and their surrounding astrocytes and pericytes. These cells interface with neurons to form a functional unit that regulates blood flow ...
The blood brain barrier (BBB) is a major obstacle to the delivery of therapeutics to the brain. Focused ultrasound (FUS) in combination with microbubbles can non-invasively open the BBB in a targeted manner. Bolus intravenous injections of microbubbles are standard practice, but dynamic influx and...
NeuroRx: The Journal of the American Society for Experimental NeuroTherapeutics The Blood-Brain Barrier: Bottleneck in Brain Drug Development William M. Pardridge Department of Medicine, UCLA, Los Angeles, California 90024 Summary: The blood-brain barrier (BBB) is formed by the brain capillary ...
This book is devoted to exploring the complexities of the blood-brain barrier. The book begins by reviewing the historical experiments that led to the concept of a barrier protecting the brain from variations in the blood. Transport kinetics and carrier-mediated processes are described, and the me...
While placental function is fundamental to normal fetal development, the blood-brain barrier provides a second checkpoint critical to protecting the fetal brain and ensuring healthy brain development. The placenta is considered the key barrier between the mother and fetus, regulating delivery of essential...
This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current prob...
The blood-brain barrier does a good job of keeping toxins out. But this tightly-packed layer of cells which separates the brain from its blood vessels is a hindrance if you want to deliver drugs into the brain. 血脑屏障可以很好地防止毒素侵入。但是,如果你想将药物输送到大脑中,这种将大脑与其...
The blood-brain barrierGrégoire, N
The blood–brain barrier and blood– tumour barrier in brain tumours and metastases Review. Nat Rev Cancer. 2020 Jan;20(1):26-41. doi: 10.1038/s41568-019-0205-x. 翻译为主,算作自己的功课记录,如果各位知友有相关见解,求慷慨分享。 脑肿瘤及脑转移瘤中的血脑屏障和血瘤屏障...
What is the Blood Brain Barrier? The blood brain barrier is responsible for controlling the movement of ions, molecules and cells between the blood and the delicate neural tissue of the brain, playing a key role in maintaining the homeostasis of the central nervous system. The blood brain barri...