The Chemistry and Biology of Left-Handed Z-DNA Rich A, Nordheim A, Wang AH. AAN Rich,A Nordheim,AHJ Wang - 《Nucleic Acid Research》 被引量: 2387发表: 1983年 Chemistry and Biology of Left-Handed Z DNA* CONTENTS PERSPECTIVE AND SUMMARY 792 INTRODUCTION 793 MOLECULAR STRUCTURE OF Z-DNA ...
Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transient localized conformational change. Few laboratories worked on the biology of Z-DNA. However, the ...
Mutagenic purine–pyrimidine repeats can adopt the left-handed Z-DNA conformation. DNA breaks at potential Z-DNA sites can lead to somatic mutations in cancer or to germline mutations that are transmitted to the next generation. It is not known whether a
Z-DNA is an alternative form of right-handed double-stranded (ds-)-B-DNA, which plays a role as a transcriptional enhancer, RNA editing and recombination. We have examined the epidermis of normal human skin for the presence of left-handed ds-Z-DNA. Z-DNA has been found in the ...
recA contains a left-handed Z-DNA-stimulated ATPase activity. This activity differs from the right-handed B-DNA-stimulated activity since it is less sensitive to increasing pH. The kinetics of ATP hydrolysis in B-DNA/Z-DNA mixing experiments showed that the turnover of the Z-DNA recA ...
A number of fully self-complementary oligodeoxynucleotides have been synthesized and examined for their ability to assume the left-handed Z-DNA conformation in high salt solutions. The B- and Z-forms are identified by circular dichroism spectra, covering both the long-(220300 nm) and short-wavele...
To determine which type of DNA is left-handed, we need to analyze the options provided:1. Understanding DNA Structures: DNA can exist in different forms based on the orientation of its helical structure. The most common forms a
- 《Journal of Molecular Biology》 被引量: 75发表: 2013年 The challenge of homogenization in metamaterials The problem of homogenization, i.e. substantial reduction of the electrical size of the average lattice constant, of electromagnetic left-handed (LH), or m... Christophe,Caloz,Anthony,.....
CGG repeats associated with fragile X chromosome form left-handed Z-DNA structure. Biopolymers 95, 174–181 (2011). Article PubMed CAS Google Scholar Fojtík, P., Kejnovská, I. & Vorlíčková, M. The guanine‐rich fragile X chromosome repeats are reluctant to form tetraplexes. Nucleic...
- 《Dna & Cell Biology》 被引量: 100发表: 2009年 Mitochondrial DNA deletions are associated with ischemia and aging in Balb/c mouse brain Deletions in the mitochondrial DNA (mtDNA) of Balb/c mouse cerebrums, resembling deletions found in elderly humans or in patients with certain disorders, ...