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Therefore, the generation of soluble form of the interleukin-6 receptor dramatically enlarges the spectrum of interleukin-6 target cells. This process has been named trans-signaling . Here, we review the involvement of both signaling modes in the biology of interleukin-6. It turns out that ...
We describe the inflammation pathway from Cholesterol to Aging. Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, Osteoporosis, Type 2 Diabetes, Dem
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This Review outlines the current understanding of the close relationship between high blood pressure (hypertension) and OA at the crossroads of epidemiology and molecular biology. As one of the most common comorbidities in patients with OA, hypertension can disrupt joint homeostasis both biophysically ...
Recent findings indicate that interleukin-1 (IL-1) and interleukin-6 (IL-6), cytokines secreted by immunologically activated monocytes and macrophages modulate neuroendocrine function. The site of production (centrally, peripherally), the site of action and the physiological significance of IL-1 and ...
Several inflammatory signals, including lipopolysaccharides (LPS), interleukin 6 (IL-6), interleukin 1 (IL-1), tumor necrosis factor α, and interferon gamma (IFN-γ) contribute to the regulation of the acute phase response in hepatocytes. The activities of the C/EBP family members are differen...
Mitsuyama K, Sata M, Rose-John S (2006) Interleukin-6 trans-signaling in inflammatory bowel disease. Cytokine Growth Factor Rev 17:451–461Kallen KJ,Galle PR,Rose-John S.New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?. Expert Opin ...