As we age, the ends of chromosomes, known as telomeres, get shorter and shorter, becoming so short that the cell dies off. This process is not merely normal, it is universal and wholly unavoidable. That doesn't mean it's easy to accept. Understanding the biology and mechanics of aging ...
Watt, D. F. (2014). "The biology of aging: implications for diseases of aging and health care in the twenty-first century," in Geriatric Neurology, 1st Edn. eds A. K. Nair and M. N. Sabbagh (Oxford: Wiley Blackwell), 3-37....
The aging process holds a special interest for physicians, who not only experience the phenomenon within themselves but also witness it in many forms in
In humans, aging is inexorable. The progressive decrease in physiological capacity and the reduced ability to respond to environmental stresses lead to increased susceptibility and vulnerability to disease. Consequently, mortality due to all causes incre
Studies of genetically mediated aging disorders have revealed the importance of lamins (intermediate nuclear filaments). For example, a mutation that prevents the protein lamin A from maturing is the cause of progeria, a disease associated with an acceleration of most aging processes and with ...
Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics The recent FDA-approval for amyloid lowering therapies reflects an unwavering commitment from the Alzheimer's disease (AD) research community to identify t... M Riessland,ME Orr - 《Journal of Prevention of...
Special Issue "The Biology of Aging and Cancer" A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging". Deadline for manuscript submissions:25 October 2022 01Special Issue Editors 02Special Issue Information ...
Summary Aging, now the focus of a rapidly expanding, if still immature, biological science, remains one of the most fundamental yet mysterious aspects of biology. Evolutionary perspectives argue that aging must be a process against which natural selection operates minimally, in a postreproductive anim...
The biology of aging : The current research agenda 来自 Wiley 喜欢 0 阅读量: 20 作者:William,B.,Ershler,Dan,L.,Longo 摘要: There has been and will continue to be a dramatic shift in the composition of our population with regard to age. Over the next several decades, the percentage of...
Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics The recent FDA-approval for amyloid lowering therapies reflects an unwavering commitment from the Alzheimer's disease (AD) research community to identify t......