The Binding of Isaac: Repentance é a edição definitiva do premiado jogo de tiro twin-stick roguelike. Ela inclui todo o conteúdo de edições anteriores de The Binding of Isaac (Rebirth, Afterbirth e Afterbirth+) além de Repentance, a última e maior expansão do jogo, ...
The Binding of Isaac Rebith é um RPG de tiro aleatoriamente gerado com elementos de ladino. Em sua jornada, Isaac irá encontrar tesouros bizarros, enfrentar criaturas estranhas, descobrir segredos e lutar do seu jeito por sua segurança. Este é o re
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Materials and Methods:Twenty partial thickness (PT) and twenty full thickness (FT) burn wounds (3 cm diameter, 100oC) were created on the dorsum of anesthetized Yorkshire pigs on day -4 (n = 8). On day 0, treatments (0.5% SN514, 1.0% SN514, Santyl, Vehicle Control (VC), and...
Nephrotoxicity is a dose limiting side effect of tenofovir, a reverse transcriptase inhibitor that is used for the treatment of HIV infection. The mechanism of tenofovir nephrotoxicity is not clear. Tenofovir is specifically toxic to the proximal convolu
Germ cell tumors (GCT) of the ovary and other locations in the female genital tract are analyzed from a clinicopathological viewpoint and reconsidered in the light of the latest genetic knowledge of their origin and information from new pluripotency and
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These channels are open, or gated, by the binding of a neurotransmitter to an orthosteric site(s) that triggers a conforma- tional change that results in the conducting state. Modulation of gating can occur by the binding of endogenous, or exogenous, modulators to allos...
Progenitors of T cells PSTPIP2: Proline–serine–threonine (PEST)–phosphatase-interacting protein 2 PTB: Phosphotyrosine-binding domains PTK: Protein-tyrosine kinase PTPN12: Protein-tyrosine phosphatase nonreceptor type 12 PTPϕ: Nonreceptor protein-tyrosine phosphatase phi PU.1: Transcription...
Autoimmune connective tissue diseases are a group of disorders with heterogeneous clinical manifestations; however, they share one common feature, namely, inflammation of connective tissue. In some of these diseases, such as morphea or lichen sclerosus,