Exoskeletons can augment the performance of unimpaired users and restore movement in individuals with gait impairments. Knowledge of how users interact with wearable devices and of the physiology of locomotion have informed the design of rigid and soft e
In places with this profile, it may be possible to reduce some climate change risks through local strategies to increase ecosystem resilience, such as pest and fire management37. In other places, for example the tropical forests of Borneo, risks to irrecoverable carbon are primarily driven by ...
During ILV formation and MVB biogenesis, the ESCRT machinery assembles in a hierarchical fashion on endosomal membranes. ESCRT-0, the best-characterized complex in MVB biogenesis, acts most upstream and serves as an endosomal clathrin adaptor that recruits ESCRT-I complex. The ESCRT-I complex ...
government websites may not be as fiery, but it is the digital equivalent of this fascist censorship. According to scholar Heike Bauer, the calculated spectacle at the institute followed ‘months of observation and threats … inaugurat[ing] a new phase in the intensification of Nazi terror.’ ...
It is defined as the sum of the transverse momenta of neutral hadrons, photons, and charged hadrons in a cone with ΔR=(Δη)2+(Δϕ)2<0.3 (0.4) around the electron (muon) candidate, excluding the contribution from the lepton itself, where ϕ is the azimuthal angle in radians. ...
It assesses the trends and issues in food, water, and energy security in South Asia and their interconnected challenges; how policy and institutional factors drive unsustainable use of resources; the environmental, social, and economic implications; and technological options to manage trade-offs and ...
1). RIPK3, although best known for its role in necroptosis (discussed later), can act in concert with RIPK1 to engage in pro-inflammatory, non-cell death signaling [9]. Here we will focus on research that indicate direct RIPK1 and/or RIPK3 involvement in pathways specifically described ...
Rather than methods which rely on generic properties of Brownian motions, our approach allows us to test which biophysical model best fits a trajectory. With the continuing improvement in spatial and temporal resolution of trajectories, these methods will be important for biological interpretation of ...
In July 2012, the ATLAS and CMS collaborations at the CERN Large Hadron Collider announced the observation of a Higgs boson at a mass of around 125 gigaelectronvolts. Ten years later, and with the data corresponding to the production of a 30-times larger number of Higgs bosons, we have...
The tumour immune microenvironment is shaped by the crosstalk between cancer cells, immune cells, fibroblasts, endothelial cells and other stromal components. Although the immune tumour microenvironment (TME) serves as a source of therapeutic targets, it