Bardet-Biedl syndrome is a model ciliopathy. Although the characterization of BBS proteins has evidenced their involvement in cilia, extraciliary functions for some of these proteins are also being recognized. Importantly, understanding both cilia and ci
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The NPIC promotes a social movement culture that is non-collaborative, narrowly focused, and competitive—re: zero-sum, Liberalism—often stifling genuine activism and innovation. The NPIC's competitive nature forces groups to vie for limited resources, often promoting their work at the expense of ...
PRDM1 represses the somatic program and promotes the progression towards germ cell differentiation33. Here, we show that gestational exposure to CD decreases SG cell numbers, affects meiosis, leads to changes in RNA expression and alters H3K4me3 occupancy at many genes in the first and third ...
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Currently, mounting studies are being performed on circRNAs, which are considered to be competing endogenous RNAs (ceRNAs) that bind to miRNAs to affect gene expression through complementary base pairing. After exposure to PM2.5, circBbs9 was upregulated and bound to miR-30e-5p, thereby elevating...
The TLR4 agonist adjuvant SLA-SE promotes functional mucosal antibodies against a parenterally delivered ETEC vaccine Npj Vaccines, 4 (1) (2019), pp. 1-8 Google Scholar [110] M.F. Klucker, F. Dalençon, P. Probeck, J. Haensler AF03, An Alternative Squalene Emulsion‐Based Vaccine Adj...
Besides Fgf10, RA signaling also plays a crucial role in lung bud formation as it promotes Wnt2/2b signaling by suppressing the Wnt inhibitor Dickkopf-related protein 1 (Dkk1); this is vital for conserving Nkx2.1 identity among the progenitors [56]. Additionally, RA signaling suppresses TGF-...
Nitrogen (N) fertilizer application promotes crop yield, but the low use-efficiency together with intensive application leads to N residues, threatening soil quality11,12. The negative effect of long-term N inputs on soil microorganisms has been extensively reported, including decrease of microbial ...