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This atypical JAK/STAT signal transduction is essential for maintaining the stability of heterochromatin.143,144,145 In a study of Drosophila, it was found that the phosphorylation of STAT can cause HP1 to break away from heterochromatin, thereby destroying the stability of heterochromatin, and the...
In line with this scavenging function, ACKR3 showed an atypical cellular localization, internalization and trafficking pattern compared to classical opioid receptors. In agreement with previous reports35,50, we observed that a much higher proportion of ACKR3 was present intracellularly compared to the c...
Osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFFs) are safety concerns not only with bisphosphonates but with other agents as well and will be discussed elsewhere. Q5.2. How Is Denosumab Used? Denosumab is a fully humanized monoclonal antibody that prevents receptor activator of...
[84]. Kazal domains often occur in tandem arrays, and serine protease inhibitors can have one or several of these domains. Moreover, atypical Kazal domains with one to two disulphide bridges have also been described [85,86]. The expression of these specific inhibitors has been associated with...
The presence of “atypical” gonads (which often developed into typical males in biopsied larvae) in sea lamprey from both the Great Lakes and Atlantic drainages is consistent with delayed gonadal differentiation but requires further study. Despite the apparent lability of the lamprey gonad, hormonal...
Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020;9:221–36. Article CAS PubMed PubMed Central Google Scholar Frieman M, Ratia K, Johnston RE, Mesecar AD, Baric RS. Severe ...
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The crystal structures of VenA are the representative structures holding an atypical DXXXXD motif, which is a counterpart of the canonical Asp-rich motif in most type I TPSs. To explore the roles of the two Asp residues, the in vitro activities of VenAD115Nand VenAD120Nwere determined in ...
recoils the sarcomere after stretch release17and is proposed to act as a molecular ruler for assembly of myosin in the A band (the region of the sarcomere where thin and thick filaments overlap)18,19. The exact stoichiometry of titin within the A band has remained a mystery, with estimates...