In the health sciences, the allostatic load model provides a widely accepted answer to this question: stress responses, while essential for survival, have negative long-term effects that promote illness. Thus, the benefits of mounting repeated biological responses to threat are......
Allostatic loadTheoretical modelBackground: Adverse birth outcomes such as preterm birth and low birth weight are significant public health concerns and contribute to neonatal morbidity and mortality. Studies have increasingly been exploring the predictive effects of maternal posttraumatic stress disorder (...
When the individual is challenged repeatedly or when the allostatic systems remain turned on when no longer needed, the mediators of allostasis can produce a wear and tear on the body that has been termed "allostatic load". Examples of allostatic load include the accumulation of abdominal fat, ...
OBJECTIVES: The purpose of this study was to investigate the relationship of allostatic load (AL), a cumulative measure of physiological dysregulation resulting from adaptation to acute and chronic stress, and delirium in the hospitalized older adult. METHOD: In this descriptive study, participants 65...
The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in the stress response, research of the effect of allostatic load on the ageing brain has been lim...
This reasoning is in line with allostatic load theory, which maintains that repeated or chronic stressors such as major life events or pressures of daily life may compromise physiological adaptation of the organism and, in turn, may entail considerable damage to bodily systems (McEwen, 1998; ...
Understanding Migraine through the Lens of Maladaptive Stress Responses: A Model Disease of Allostatic Load The brain and body respond to potential and actual stressful events by activating hormonal and neural mediators and modifying behaviors to adapt. Such resp... David,Borsook,and,... - 《Neuro...
The Quadratic Hazard Model for Analyzing Longitudinal Data on Aging, Health, and the Life Span Allostatic loadStress resistancePhysiological normsAn approach to analyses of longitudinal data on aging, health, and longevity. Stochastic process models of ... AI Yashin,KG Arbeev,I Akushevich,... ...
In the past few decades, the concept of allostatic load has been championed by Bruce McEwen (Karatsoreos and McEwen, 2011), whereby it is hypothesized that the continual wear and tear from stress exposure results in an increased vulnerability to the adverse effects of stress. In this context,...
Allostatic load, a composite measure of accumulated physical wear and tear, has been proposed as an early sign of physiological dysregulation predictive of health problems, functional limitation, and disability. However, much previous research has been cross sectional and few studies consider repeated me...