Briefly, for each sample, the raw sequence reads were aligned into BAM files using STAR103 (v.2.7.4a) two-pass alignment with GRCh38 as the reference. The resulting BAM files were then quantified as a raw count-matrix using read feature counts using Subread104 (v.2.0.1). For both ...
Dies, Martin– FBI Vault Release #1 – This Congressman from Texas was known as the founder of the House Un-American Activities Committee. The FBI file contains correspondence between him and J. Edgar Hoover, as well as the results of investigations regarding potential extortion violations. Dole,...
Vasculature was labelled with intravenous injection of FITC–dextran (2-MDa, Sigma-Aldrich; FD2000S) or Texas red Dextran (70 MDa, Life Technologies catalogue number D-1864), ten minutes before imaging. To visualize arterioles specifically, Hydrazide (Alexa Fluor™ 633 Hydrazide Life Technologies ...
The variations in diagnostic care pathways for both the benign cohort and malignant cohort are presented for the top-three activities performed, over the course of three consecutive hospital visits inFigure 1andFigure 2. Horizontally aligned care activities belong to the same diagnostic care pathway....
Background: The UK 100,000 Genomes Project was a transformational research project which facilitated whole genome sequencing (WGS) diagnostics for rare diseases. We evaluated experiences of introducing WGS in Northern Ireland, providing recommendations f
Out-of-sample data from a new MRI study were aligned to the corresponding epoch of the normative trajectory, using maximum likelihood to estimate the study specific offsets (random effects) for three moments of the underlying statistical distributions: mean (\(\mu \)), variance (\(\sigma \)...
I’m not shocked. Even as experienced political operatives holding views aligned with mine were touting the possibility of a big win for the Democrats, my judgment was telling me all along that this was going to be a very close election. ...
For presidential candidates running since 1973 the question about abortion rights has been about two things: where they are more aligned in the culture-battle camp, and what kind of judges and Supreme Court justices they would appoint. The matter was almost entirely an issue for the courts, whi...
Alzheimer’s disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain’s functional connectivity. Assessing these alterations has become a topic of increasing interest. However, a few studies have examined differ
Although often presenting distinctly in the clinic, heterogenous TBI cases are generally stratified by their severity. The classifications of mild (mTBI/concussion), moderate, and severe TBI were established following the publication of the Glasgow Coma Scale (GCS) in 1974, which is a widely ...