How to select favorable and promising alleles and genotypes for breeding: A case study of rice blast resistance genes in Southern and Northeastern Chinadoi:10.1016/j.cj.2024.12.011Rice blastXian and Geng type r
Nevertheless, the challenge of identifying the actual causal genes and pathways and their biological effects on altering disease risk remains for many identified susceptibility regions. It is this fundamental knowledge that will underpin the revolution in patient stratification, the discovery of therapeutic...
cells, as we found enrichment of eGenes for drug targets at different phases of development where such eQTL intersect with GWAS variants (Supplementary Fig.1c). Notably, eGenes were identified/scored through GWAS–eQTL colocalization analysis9, enabling directionality and magnitude-of-effect integrati...
Is it the genetic composition of the population/species first and foremost? Or is it the local ecosystem, in which said population has created the problem of invasion or disease it is now being targeted for? Given gene drives' self-propagating feature, can we understand the intervened-upon as...
However, alleles of genes that contribute to increased fruit size in tomato (Nesbitt and Tanksley, 2002) or increased apical dominance in maize (Clark et al., 2004) are also found in their wild or feral relatives, although at lower frequencies. Given the large store of genetic variation in ...
Therefore, it is safe to conclude that the inflation rate depends on the composition of the sample. For example, when the study sample is comprised of admixed individuals derived from intermating between exactly 2 ancestral populations, the type I error inflation can be very small when the ...
Because the current phylogenetic analysis did not include all species, it is possible that the species identified as the source of introgressed alleles may simply be close relatives of the actual parental species. Nevertheless, the phylogenetic framework was a useful approach in determining that ...
(TccX10). The composition of the 22 putativeTcm-specific genes were as follows: 11 TcMUCII mucin genes; 1 acetyltransferase (MOQ_006101); 5 putative genes with weak hits to microbial sequences (MOQ_006053, MOQ_007485, MOQ_009774, MOQ_006631, MOQ_003304); and 5 putative genes with no ...
Genetic background affected hepatic gene expression in the CC overall, but diet macronutrient differences also altered expression of a specific subset of genes. Changes in macronutrient composition altered gene expression related to metabolic processes, while genetic background heavily influenced a broad ra...
two populations is likely contributed by several other reasons, including: (1) different environments tested; (2) different statistical methods employed; and (3) different composition of the two panels (which share B73 and HP301 haplotypes only).Vgt1andVgt2, the leading loci for maize flowering...