By this model, we achieved aged-like microglia in non-aged brains and confirmed that aged-like microglia per se contribute to cognitive decline. Collectively, our work provides a comprehensive resource for decoding the aging process of microglia, shedding light on how microglia maintain brain ...
1a). Gene Ontology (GO) and protein–protein interaction network analyses showed that these 381 activated genes are functionally associated with cell chemotaxis and migration (Fig. 1b) and form two major gene hubs that are associated with chemotaxis (for example, C5ar1, Cd14 and Vcam1) and ...
Mouse phenotype annotations, using the mammalian phenotype (MP) ontology, for both the gene and the QTL were made by the Mouse Genome Informatics (MGI) database and imported via the mouse MP pipeline. Of the 18 genes, several have a role in drug transport and metabolism (Abcc2, Cyp2e1 ...
GO: gene ontology. BP: biological process. MF: molecular function. CC: cellular component KEGG分析得到112条信号通路(表3),根据P<0.01,筛选出86条通路,绘制气泡图(图5)。KEGG分析结果表示白藜芦醇抗OSCC的相关靶点主要集中在PI3K/AKT信号通路,脂质、流体剪应力与动脉粥样硬化,化学致癌-DNA加合物,细胞色素...
Gene ontology (GO) analysis revealed that these genes were mostly enriched in the function of the nervous system (Additional file 1: Fig. S4 and Additional file 2: Table S8), including “positive regulation of neuron differentiation” (GO:0045666) and “neuron to neuron synapse” (GO:0098984...
Service-oriented architecture (SOA) is an architectural model which advocates for the provisioning of functionalities in the form of services. SOA is believed to facilitate the growth of large-scale enterprise systems, allow Internet-scale provisioning and service usage, and reduce costs through coopera...
Their system have components as follows: software agents for supporting CRPs; communication mechanisms allowing agents communicate with each other; two ontologies (application domain ontology and problem domain ontology) that let agents use a common semantics. 3.4.4. MENTOR: a graphical monitoring tool...
The causes of non-acceptance of evolution are groupable into five categories: inadequate understanding of the empirical evidence and the content of modern evolutionary theory, inadequate understanding of the nature of science, religion, various psycholog
The coffee berry borer, Hypothenemus hampei, is the most economically important insect pest of coffee worldwide. We present an analysis of the draft genome of the coffee berry borer, the third genome for a Coleopteran species. The genome size is ca. 163
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we use single-cell RNA seque