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Despite decades of research, the principles and mechanisms underlying all steps of PAR removal remain actively studied. In this work, we synthesise well-defined PAR branch point molecules and demonstrate that PARG, but not ARH3, can resolve this distinct PAR architecture. Structural analysis of AR...
We outline here the main steps of the solution, while the computations are performed in the Mathematica notebook Ex3.9_DirectExtraction.wl [1]. Since we are considering a triangle integral, all quadruple cuts vanish. The coefficients of the box numerator are thus zero. We parametrise the triang...
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3.something made real, tangible, or specific 4.(Geological Science) any of various rounded or irregular mineral masses formed by chemical precipitation around a nucleus, such as a bone or shell, that is different in composition from the sedimentary rock that surrounds it ...
PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes. J. Biol. Chem. 285, 14415–14423 (2010). Article CAS PubMed PubMed Central Google Scholar Martin, N. et al. PARP-1 transcriptional activity is regulated by sumoylation upon heat shock...
3.declension- a downward slope or bend declivity,downslope,declination,decline,fall,descent downhill- the downward slope of a hill incline,slope,side- an elevated geological formation; "he climbed the steep slope"; "the house was built on the side of a mountain" ...
2a). Although the yeast two hybrid and FRET analysis showed that FREE1 did not exhibit a direct interaction with components of the ATG conjugation system ATG5, ATG12, ATG16 or other ATG proteins (Supplementary Fig. 11), colocalization and co-immunoprecipitation (co-IP) experiments in ...
2. The introduced ncAA carries bioorthogonal reactivity for the site-specific conjugation of biophysical probes featuring negligible interference with components of the cell3,4. A variety of chemical strategies termed click labeling emerged for site-specific conjugation of sensor molecules to ncAA under ...
Biaryl scaffolds are found in natural products and drug molecules and exhibit a wide range of biological activities. In past decade, the transition metal-catalyzed C–H arylation reaction came out as an effective tool for the construction of biaryl motif