凝血酶敏感蛋白-2也被称为THBS2、TSP2、TSP-2。凝血酶敏感蛋白-2(TSP2)是一种抑制肿瘤生长和血管生成的抗血管生成基质细胞蛋白。介导细胞间和细胞与基质相互作用的粘附性糖蛋白。CD36配体介导抗血管生成特性。THBS2基因内含子区的2个SNP(rs6422747和rs6422748)与IDD的易感性有关。然而,它们与IDD的严重程度无关...
小鼠CD99L2 转录变体1 基因全长ORF克隆 重组狗IGFBP5 / IGFBP-5 蛋白 (Fc 标签) 人CTSW 基因全长ORF克隆 重组人CXCL12 / SDF-1 蛋白 小鼠COX7B 基因全长ORF克隆 Immunoprecipitation/ IP Kit - Anti-Nucleoprotein Immunomagnetic Beads IP 5 mL
In conclusion, TGF-β1-THBS2-integrin α v β 3 /CD36-MAPK cascade forms a complex feedback circuit to mediate reciprocal interactions of pancreatic cancer cells-CAFs. THBS2 may act as a novel therapeutic-target to block the cancer-stroma communication. Copyright 2021. Published by Elsevier ...
6A-C). Furthermore, RP11-417E7.1 depletion downregulated the expression of Vimentin, THBS2, β-catenin, and the M2 macrophage markers CD163 and ARG1, while THBS2 overexpression restored their expression (Figs. 6D-E). Moreover, the silencing of RP11-417E7.1 markedly extended mouse survival ...
Ligand for CD36 mediating antiangiogenic properties. 2 SNPs in the intron region of THBS2 gene (rs6422747 and rs6422748) were associated with susceptibility of IDD. However, they were not related with severity of IDD, including the total number of degenerative disc and level of IDD. ...
A total of 58 SNPs from 21 genes, including CD36, ITGA2, VCAM1, THBS2 showed association at a significance level of P¼0.05. The genotype distribu- tions of the 58 SNPs in control samples are all under HWE (PHWEo0.05). The strongest association was observed at rs2071303 within the...
43 have reported that the inhibitory role of THBS2 in tumors is related to its multiple interactions with cell surface receptors (LRP, CD36, CD47, and numerous integrins), ECM components, growth factors (TGF-β, FGF2), enzymes (MMPs, elastase), and calcium binding, the effect and ...
6F). As revealed by flow cytometry, mice bearing sh-AGAP2-AS1-treated ACHN cells had fewer CD163+ cells, while mice bearing sh-AGAP2-AS1 + oe-THBS2-treated ACHN cells had increased CD163+ cells (Additional file 1: Figure S1G). Finally, H&E staining showed that mice bearing ...