凝血酶敏感蛋白-2也被称为THBS2、TSP2、TSP-2。凝血酶敏感蛋白-2(TSP2)是一种抑制肿瘤生长和血管生成的抗血管生成基质细胞蛋白。介导细胞间和细胞与基质相互作用的粘附性糖蛋白。CD36配体介导抗血管生成特性。THBS2基因内含子区的2个SNP(rs6422747和rs6422748)与IDD的易感性有关。然而,它们与IDD的严重程度无关...
THBS2 could bind to CD36 protein on the membrane of GC cells, then activate its downstream Akt/Erk signalling pathway, which enhanced the invasion and metastasis abilities of GC cells (IDDF2024-ABS-0370 Figure 3).Xinyu WangJingyu Deng
Thrombospondin-2 is also known as THBS2, TSP2, TSP-2. Thrombospondin-2 (TSP2) is an anti-angiogenic matricellular protein that inhibits tumor growth and angiogenesis. Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic propertie...
(1)A549细胞中THBS2与CD36相互结合 STRING数据库评估THBS2与CD36能否相互结合;Co-IP实验进一步验证 A549细胞中THBS2与CD36的结合情况。 (2)A549细胞中下调THBS2对PI3K/AKT/mTOR信号通路的影响 Westernblot实验检测下调THBS2对PI3K/AKT/mTOR信号通路相关信号分 ...
molecular subtypes (CMS) of CRC [36]. THBS2 expression was the highest in the CMS4 of CRC, mesenchymal subtypes of OV, and HNSC, with CMS4 and mesenchymal subtype characterized by EMT upregulation [36,37,38] (FigureS1I-K). Consistently, high THBS2 levels were more prevalent in the ...
小鼠CD99L2 转录变体1 基因全长ORF克隆 重组狗IGFBP5 / IGFBP-5 蛋白 (Fc 标签) 人CTSW 基因全长ORF克隆 重组人CXCL12 / SDF-1 蛋白 小鼠COX7B 基因全长ORF克隆 Immunoprecipitation/ IP Kit - Anti-Nucleoprotein Immunomagnetic Beads IP 5 mL
6F). As revealed by flow cytometry, mice bearing sh-AGAP2-AS1-treated ACHN cells had fewer CD163+ cells, while mice bearing sh-AGAP2-AS1 + oe-THBS2-treated ACHN cells had increased CD163+ cells (Additional file 1: Figure S1G). Finally, H&E staining showed that mice bearing ...
6F). As revealed by flow cytometry, mice bearing sh-AGAP2-AS1-treated ACHN cells had fewer CD163+ cells, while mice bearing sh-AGAP2-AS1 + oe-THBS2-treated ACHN cells had increased CD163+ cells (Additional file 1: Figure S1G). Finally, H&E staining showed that mice bearing ...
In conclusion, TGF-β1-THBS2-integrin α v β 3 /CD36-MAPK cascade forms a complex feedback circuit to mediate reciprocal interactions of pancreatic cancer cells-CAFs. THBS2 may act as a novel therapeutic-target to block the cancer-stroma communication. Copyright 2021. Published by Elsevier ...
(1:1000, GTX112729; Gene Tex, Irvine, CA, USA), CD 81 (1:500, GTX101766; Gene Tex), α-SMA (1:1000, bsm-52396R; Bioss Antibodies Inc, Woburn, MA, USA), β-catenin (1:1000, GTX632676; Gene Tex), Fibronetin (1:500, ab2413; Abcam, Cambridge, MA, USA), Vimentin (1:...