In vitro and mouse studies suggest that disrupting interactions between TSP-1 and CD47 could help reduce bone resorption to treat myeloma-related bone disease and osteoporosis. Further details on the research, next steps and licensing status are discussed in the article.Science-Business eXchange...
它对血小板聚集、血管生成和肿瘤发生发挥作用。在正常组织中,它是新血管形成和肿瘤发生的天然抑制剂。THBS-1还可正向和负向调控内皮细胞黏附、运动和生长。通过阻断THBS-1与细胞表面受体(CD47)结合,正常组织几乎对肿瘤辐射治疗产生免疫,并有助肿瘤死亡。 THBS1, thrombospondin 1 分子靶点种属信息...
CD47; thrombospondin-1 (TSP-1; THBS1)In vitro and mouse studies suggest that blocking CD47 signaling could help boost the efficacy of radiotherapy while protecting healthy tissues. Further details on the research, next steps and licensing status are discussed in the article.Science-Business eXchange...
g Co-immunostaining for CD8 and CD47 (top) or CD36 (bottom) in primary lesions of MTO-bearing WT mice (n = 3 mice). White arrowheads denote co-stained cells. h, i FACS analyses of indicated cell proportions in CD8+ (CD3+CD8+) T cells sorted from CD47-/- h or CD36-/- i...
CD47 and CD36 cell surface proteins were originally proposed to serve as Thbs1 receptors, where they mediate signaling associated with secreted extracellular Thbs111. While the field now understands that CD36 and CD47 are multiligand receptors with additional important functions in fatty acid transport...
1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with various proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase. Positive and negative modulation of endothelial cell adhesion, motility, ...
TSP1 interacts with at least 12 cell adhesion receptors,including CD36,αv integrins,β1 integrins,syndecan,and integrin-associated protein (IAP or CD47).It also interacts with numerous proteases involved in angiogenesis,including plasminogen,urokinase,matrix metalloproteinase,thrombin,cathepsin,and ...
It has been reported that Thbs1 can function by binding to receptors of cell surface like integrins and CD47 on the one hand, and enter cells by exosome delivering on the other hand [34,[44], [45], [46]]. Therefore, we initially treated THP-1 cells with gradient-diluted recombinant Th...
Thrombospondin-1 promotes Tumor progression in cutaneous T-cell Lymphoma via CD47. Leukemia. 2020;34(3):845–56. 12. Chen X, Guo ZQ, Cao D, Chen Y, Chen J. MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1/FAK/Akt signaling. Cell Death Dis. 2021;12(...
)作者简介:包楠丁,女,硕士.通讯作者:贾永峰.摘要:近年来,在多种类型的肿瘤中均发现了血小板凝血酶蛋白Ｇ１(t h r o m b o s p o n d i n Ｇ１,T H B S １)的异常表达,其是近年来肿瘤领域研究的热门靶点基因.T H B S １作为一种多功能蛋白,在肿瘤中的作用较为复杂,对肿瘤的影响机制尚不完全...