ChromatinHistonesNuclear Proteins染色质组蛋白类Histones are the predominant protein components of chromatin and are subject to specific post-translational modifications that are correlated with transcriptional competence. Among these histone modifications are acetylation, phosphorylation and methylation, and recent...
Eukaryotic histones (components of the eukaryotic nucleosome) are believed to have originated and evolved from archaeal families of DNA-binding proteins, also called archaeal histone-like proteins or archaeal histones15,16,17. Many archaeal histone-like proteins have been resolved by X-ray crystallograp...
Second, mapping the chromatin features of HACs using sequencing-based approaches would become possible. For instance, it is imperative to know where functional centromeres are located relative to other functional genetic elements that the HACs are engineered to carry. The highly repetitive sequences ...
Innate immunity is a key element of the immune response including several cellular components such as macrophages, NK cells, and neutrophils, which provide rapid first-line defence against pathogens. The function of these cells declines with age. Although their production increases with age, in the ...
Figure 1. External entrainment and hierarchical organization of the mammalian circadian clock and core components of its molecular clock Light-dark and feed-fast cycles entrain the master (SCN) and peripheral clocks, respectively. Transcriptional activators BMAL1 and CLOCK bind the E-box motifs of cl...
The genes identified are involved in processes such as RNA biology (transcription, translation and regulatory mechanisms), membrane functions (e.g. signalling, transport and targeting), membrane structural components, cell division, and proteasome processes. The transcriptomes of control wild type and 5...
Chromatin immunoprecipitation experiments demonstrated that Nub binds to octamer-containing promoter fragments of several immune genes. Gene expression profiling revealed that Drosophila Nub negatively regulates many genes that are involved in immune and stress responses, while it is a positive regulator of ...
trans ocation o AIF to nuc ei triggers chromatin condensation and DNA ragmentation (12). The endop asmic reticu um (ER) is a continuous membrane network in which secreted and membrane proteins mature with the assistance o ER umina chaperone proteins, such as g ucose- ...
OCA-Sstimulated proteins were identified as Hsp70 and Sti1, which are components of molecular chaperones (reviewedin Fryd- octamer-/Oct-1-dependent transcription from the H2B promoter, but not from the IgH promoter, whereas the man and Hohfeld, 1997). reverse was true for OCA-B. A weak ...
Histones are found in the nuclei of all eukaryotic cells, where they play a role in packaging DNA into a structural unit known as a nucleosome or chromatin [47]. Consequently, they are not usually secreted outside the cells. We also identified such ‘somatic’ proteins in the secretions of...