酞胺***酮，反应停（原用作妊娠妇女的镇静药，但在20世纪60年代因发现会引起胎儿四肢畸形而被禁用）a sedative drug which was given to pregnant women until, in the 1960s, it was found to have prevented some babies from developing normal arms and legs ...
"The discovery of thalidomide's mechanism of action was surprising in many ways, but it showed us how to trigger the rapid degradation of two zinc finger transcription factors that we otherwise had no idea of how to drug," said Benjamin Ebert, an institute member in the Broad Cancer Program...
待解决 悬赏分:1 - 离问题结束还有 Facts: Thalidomide Tragedy (反应停事件) in 1960s-1970s问题补充:匿名 2013-05-23 12:21:38 事实:沙利度胺的悲剧(反应停事件)在20世纪60年代20世纪70年代 匿名 2013-05-23 12:23:18 事实:萨立多胺悲剧(反应停事件)在1960年代和1970年代 匿名 2013-05-23 1...
Thalidomideis associated with the development of a sensory-predominantneuropathywith prolonged use.53In contemporary practice,thalidomideis used primarily in the treatment ofmultiple myeloma, although the drug was introduced in the 1960s as a sedative.Lenalidomideandpomalidomideare newer formulations and asso...
In recent years, thalidomide and similar molecular entities have reentered the clinical milieu and have been approved for several indications. Mention thalidomide to a pharmacist who has been around for a few decades, and you may see a visible shudder. Prescribed in the 1960s to help people ...
alike to travel around appreciate the scenery landscape. 象旅行赞赏风景风景。 [translate] aGelgene's drug is thalidomide which earned world-wide notoriety in the 1960s for causing birth defects. The story of its reincarnation as an AIDS and cancer treatment shows how the political environment ...
Thalidomide--banned from clinical use in the 1960s because of severe teratogenicity--is now back in clinical practice as an effective agent in the treatment of relapsed and refractory multiple myeloma. Several clinical trials have determined that thalidomide is active in 25-35% of patients with re...
Thalidomide is a drug with bad reputation from the 1960's as it appeared to be teratogenic by causing foetal anomalies. However, in the beginning of 1990s it was shown very antiangiogenic. Its immunological effects were known already from earlier studies. Nowadays its use is accepted in myeloma...
Melphalan prednisone was the mainstay of myeloma treatment in the 1960s with 50% of overall response, yet this treatment was associated with a short duration of response and a poor median overall survival (only 3 years). Thalidomide, initially used as an antiemetic and sedative agent, was demo...
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