It was concluded that when performing thalassemia screening tests in Thailand, fresh EDTA blood must be used for OFT test and MCV determination. However, although MCH seemed to be the most stable parameters, thalassemia screen cannot rely only on MCH value. Therefore,...
Background: Thalassemia is a commonest genetic blood disorder in India which can be prevented by antenatal screening and prenatal diagnosis. Aim of the study was to screen antenatal women and their spouses to detect "couples at risk" of thalassemia major births and offering them genetic counseling...
The screening test includes osmotic fragility (OF) test, dichlorophenol-indophenol (DCIP) test, quantitation of HbA 2 , HbE screening and PCR analysis. Five hundred blood samples were collected from a population living in Uttaradit, Phetchabun, and Phitsanulok. The results showed a high frequency...
Single-tube multiplex-PCR screen for common deletional determinants of alpha-thalassemia. Blood 2000;95:360 –362. 32. Old JM. DNA-based diagnosis of the hemoglobin disorders. In: Steinberg MH, Forget PG, Higgs DR, Nagel RL, editors. Disorders of hemoglobin: genetics, pathophysiology, and ...
Single-tube multiplex-PCR screen for common deletional determinants of alpha-thalassemia. Alpha-thalassemia is very common throughout all tropical and subtropical regions of the world. In Southeast Asia and the Mediterranean regions, compound he... SS Chong,CD Boehm,DR Higgs,... - 《Blood》 被...
How can a blood test detect thalassemia? Doctors diagnose thalassemias using blood tests, including a complete blood count (CBC) and special hemoglobin tests. A CBC measures the amount of hemoglobin and the different kinds of blood cells, such as red blood cells, in a sample of blood. ......
This study was using cord blood electrophoresis to screen alpha tha-lassemia in 204 newborns who were born in our hospital obstetrics from April to Dec. 1994. We identified 19 carriers of standard gene alpha thalassemia(11%) and 5 carriers of arrested gene (7%). Re-examination affer 3 to ...
Genetically, it is characterized by a mutation in the α- or β-globin gene causing decreased or no production of the α- or β-globin chain in red blood cells. This condition induces hemolytic anemia, which later develops into chronic anemia. Patients suffering from this disease require ...
Background: Thalassemia is a commonest genetic blood disorder in India which can be prevented by antenatal screening and prenatal diagnosis. Aim of the study was to screen antenatal women and their spouses to detect "couples at risk" of ... S Mendiratta,M Mittal,F Naaz,... - 《Internationa...
Enrolled 951 adults of Dai ethnicity Traditional hematological screen: 951 blood samples: routine blood examination + Hemoglobin electrophoresis analysis 452 positive cases screened by RBC; 115 suspected carriers of α-thalassemia and 279 suspected carriers of β-thalassemia by HbA2 (no composite α−...