Table 3 Basic patient information and transfusion burden Full size table Analytical results in the formal survey WTP for temporary alleviation of anemia status Following randomization, 74 patients participated in the survey for the first set of bidding scenarios, and 75 patients engaged with the second...
Supplementary information Supplementary information, Figure S1 Characterization of β-thalassemia patient-specific iPS cells. (PDF 218 kb) Supplementary information, Figure S2 Characterization of derived hES cells. (PDF 242 kb) Supplementary information, Figure S3 Validation of piPS cell pluripotency. (PDF...
Results Figure 1 demonstrates exemplary T2* (left) and T2 (right) images from the same patient, where blood signals are well suppressed and clearly defined myocardial borders shown. Figure 2 shows the correlation curve between T2* and T2 drawn from 132 thalassemia patients. There was clearly a...
MLPA analysis showed half dosages for ten probes located in the HBB in patient 1 (SEA-HPFH) and twenty probes located in the HBB, HBD, and HBBP1 in patient 2 (Gγ+(Aγδβ)0-thalassemia) Full size image Comparison of hematological parameters between Chinese Gγ+(Aγδβ)0/βN-thal...
Functional correction of large factor VIII gene chromosomal inversions in Hemophilia A patient-derived iPSCs using CRISPR-Cas9 Cell Stem Cell, 17 (2015), pp. 213-220 View PDFView articleView in ScopusGoogle Scholar 47 Y. Guan, Y. Ma, Q. Li, Z. Sun, L. Ma, L. Wu, L. Wang, L. ...
It is now universally recognized that thalassemia, like other chronic diseases, has important psychological implications. The way in which the family and the patient come to terms with the disease and its treatment will have a critical effect on the patient's survival and quality of life, and ...
The expression of a common AγT chain variant was detected in samples derived from Patient 2. After treatment, the two patients had equal amounts of alpha and non-alpha chains in their blood after treatment as that of healthy donor. Source data Extended Data Fig. 3 Representative indel ...
Molecular analysis of the erythroid phenotype of a patient with BCL11A haploinsufficiency 2021, Blood Advances Citation Excerpt : We also observed an increase in HBBP1 expression in BCL11A-null HUDEP2 cells (supplemental Figure 3D). HBBP1 has been implicated in HbF expression,59-61 chromatin archi...
Correspondence toKevin H. M. Kuo. Ethics declarations Ethics approval Not applicable. Consent to participate Not applicable. Competing interests The authors declare no competing interests. Additional information Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in publishe...
Coronavirus disease 19 (COVID-19) is an infectious disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) causing acute systemic disorders a