Thalassemiais the result of the deficient synthesis of one of thepolypeptidechains of the hemoglobin molecule. As a result, the ability of red blood cells to transport oxygen in the body is reduced. Depending upon its degree of severity, thalassemia may be major, minor, or intermedia.Thalassemia...
β-Thalassemia minor (Trait) Reduced or no activity of 1 of 2 β-globin genes Mild microcytic anemia Increased HbFLimited clinical manifestations Abbreviations: Hb, hemoglobin; NTD, nontransfusion dependent; RBC, red blood cell; TD, transfusion dependent. Survival in this population has improved wit...
In adults: bone densitometry to assess for osteoporosis; serum alpha-fetoprotein concentration for early detection of hepatocarcinoma in those with hepatitis C and iron overload; regular gallbladder echography for early detection of cholelithiasis for those at risk. Agents/circumstances to avoid: alcohol...
Thalassemia minor, the Gilbert mutation, and the risk of gallstones. Haematologica 2003; 88: 1106–1109. CAS PubMed Google Scholar Galanello R, Perseu L, Melis MA, et al. Hyperbilirubinaemia in heterozygous beta-thalassaemia is related to co-inherited Gilbert's syndrome. Br J Haematol 1997...
A subgroup analysis revealed that the HBsAb positivity rate was lower in children with β-thalassemia minor compared to those with α-thalassemia minor (P = 0.001, 95% CI: 0.097 ∼ 0.536). Adverse reactions after hepatitis B vaccination were dominated by general reactions, with a ...
β-thalassemia major, usually pres- ents as severe anemia requiring lifelong transfusions; however, at times, this has a variable, milder presentation.9 Therefore, effective premarital screening in regions of the world where α0-thalassemia carriers or β-thalassemia minor are prevalent is important...
The effect of hydroxyurea on the coagulation system in sickle cell anemia and β-thalassemia intermedia patients: A preliminary study Hydroxyurea (HU) has been shown to reduce the frequency of vaso-occlusive manifestations in both adults and children with sickle cell disease (SCD), and th... A...
β-Thalassemia intermedia is a clinical condition of intermediate gravity between β-thalassemia minor, the asymptomatic carrier, and β-thalassemia major, the transfusion-dependent severe anemia. It is characterized by a significant clinical polymorphism, which is attributable to its genetic heterogeneity....
Thalassemia minor is char- acterized by reduced MCV and MCH, with increased HbA2 level.33 The peripheral blood smear in affected individuals demon- strates RBC morphologic changes with microcytosis, hypo- chromia, anisocytosis, poikilocytosis, and nucleated RBCs. The number of erythroblasts is ...
People with beta-thalassemia intermedia may require blood transfusions at some point(s) in their life. Beta-Thalassemia Minor Characterized by below-average hemoglobin and red blood cell size. Generally, people with beta-thalassemia minordo not have severe symptoms ...