Decreased Th1-like and Increased Th2-like Cells in Systemic Lupus Erythematosus[J] . M Funauchi,S Ikoma,H Enomoto,A Horiuchi.Scandinavian Journal of Rheumatology . 1998 (3)Funauchi M,Ikoma S,Enomoto H,et al.Decreased Thl-like and increased Th-2 like cells in systemic lupus erythematosus. ...
After boost, antigen targeting to cDC1s improved the TH1 cell response and induced TH1-like TFHcells that led to an increase in specific antibody titers and IgG class switch. Additionally, a population of regulatory Tcells was also observed. Antigen targeting to cDC2s did not improve the ...
143]. Subsequent exposure of IFNγ-primed Tregs to IL-12 renders Tregs dysfunctional and favors the polarization of Th1-like IFNγ-producing Tregs leading to a disrupted regulation of type-I inflammatory responses [151]. However, the upregulation of IFNγ at RNA and protein levels by...
CONCLUSION/INTERPRETATION: Overwhelming production of IFN-gamma seen in peripheral blood mononuclear cells from high-risk first-degree relatives of children with Type I diabetes suggests a Th1-like immune deviation in the prediabetic phase. 展开 ...
Th1-like Tfh cells, but not Th1 cells, are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses. Our study suggests that specific modulation of the Th1-like Tfh cell response during infection or vaccination may augment the ...
Therefore, a loss of BCATc may generate Th1-like Treg cells and point to its regulatory role in the differentiation of CD4+ T cells.The Journal of ImmunologyTanner WetzelChristie AdamRebekah BetarMike BoyerElitsa Ananieva
A Single Treatment with Adjuvant Stimulates Th1-Like Cytokines and Downregulates Th2-Mediated Primary and Secondary Allergic ResponsesCD4+ T cells play a central role in most effective immune responses to antigens and pathogens. Since the phenotype of CD4+ T cells induced defines the nature of the...
Later, IFN-based therapy restrains the fraction of regulatory T cells that can be polarized into IFN-γ-producing Th1-like regulatory T cells known to contribute to chronic immune activation in type 1 inflammation. Indeed, Th1-like regulatory T cell frequency significantly declines after 30 d of...
NK cell-deficient mice develop a Th1-like response but fail to mount an efficient antigen-specific IgG2a antibody response. J. Immunol. 163: 5298.Satoskar, A. R., L. M. Stamm, X. Zhang, M. Okano, J. R. David, C. Terhorst, and B. Wang. 1999. NK cell-deficient mice develop a...
Stressed Rats Fail to Expand the CD45RC+CD4+ (Th1-Like) T-Cell Subset in Response to KLH: Possible Involvement of IFN-γ (1995). Stressed rats fail to expand the CD45RC+CD4+ (Th1-like) T cell subset in response to KLH: possible involvement of IFN-gamma. Brain Behav... M. Flesh...