induces an ESAT-6-specific Th1-type immune response and CTL effects following intranasal immunizationThe flagellin component FliC ofis capable of activating the innate immune systemspecific interactions with TLR5 and can also act as a carrier of foreign antigen to elicit antigen-specific immune ...
CpG ODNs are ligands for TLR9 that can activate both the TLR9-MyD88-IRF7 and TLR9-MyD88-NFκB signaling pathways to induce type I IFN and pro-inflammatory cytokine production by innate immune cells, leading to a Th1-type adaptive immune response [11]. Since Th1-type immune cells play a...
et al. Glyceraldehyde-3-phosphate dehydrogenase from Eimeria acervulina modulates the functions of chicken dendritic cells to boost Th1 type immune response and stimulates autologous CD4+ T cells differentiation in-vitro. Vet Res 51, 138 (2020). https://doi.org/10.1186/s13567-020-00864-z ...
This is the first clinical study showing that CpG ODN (K3) activated innate immunity and elicited Th1-type adaptive immune response and cytotoxic activity in cancer patients. CpG ODN (K3) was well tolerated at the dose settings tested, although the maximum tolerated dose was not determined. Tr...
Vet Res (2018) 49:108 https://doi.org/10.1186/s13567-018-0602-2 RESEARCH ARTICLE Open Access The adjuvant G3 promotes a Th1 polarizing innate immune response in equine PBMC Stina Hellman* , Bernt Hjertner, Bror Morein and Caroline Fossum Abstract The immunomodulatory ...
ARTICLES T-bet-independent Th1 response induces intestinal immunopathology during Toxoplasma gondii infection Ame´rico H Lo´pez-Yglesias1, Elise Burger1, Alessandra Araujo1, Andrew T Martin1 and Felix Yarovinsky1 Coordinated production of IFN-c by innate and adaptive immune cells is central for...
Moreover, the adoptive transfer of GrpE-BMDCs induced a Th1-type immune response. Conclusions Uu-GrpE could stimulate the maturation and polarization of BMDCs. Moreover, it could induce Th1 immune response as a candidate protein vaccine for Ureaplasma urealyticum. KEYWORDS: Ureaplasma urealyticum ...
Collagen Type ICholesterolAtherosclerotic lesions contain T lymphocytes, which orchestrate adaptive immunity and regulate many innate immune pathways. This study examined the influence of Th1 and Th2 helper cell subsets on atherogenesis in two ApoE / mouse strains, C57BL/6 and BALB/c, which display...
,32 who showed in vitro that naive neonatal human T cells can be skewed toward a Th1-type response upon exposure to L. lactis-primed DCs. This is the first report seeking the use of probiotic-derived antigen-displaying particles to “jump-start” the neonatal immune system for the purpose ...
1-8 Once antigen has been detected by an innate immune cell, this information is communicated to T and B cells of the adaptive immune system.1,3,4 Although T and B cells need to be instructed how to respond (i.e., what specific cytokines to secrete, what antibody isotype(s) to make...