Manipulation of the Th1/Th2 cell balance: an approach to treat human autoimmune diseases? Autoimmunity 23: 53- 68.Adorini L, Guery JC, Trembleau S: Manipulation of the Th1/Th2 cell balance: An approach to treat human autoimmune diseases?. Autoimmunity 23:53-68, 1996...
The study of autoimmune disease in the context of T-helper type 1 (Th1) and T-helper type 2 (Th2) CD4+ T-cell responses demonstrates that the relative contribution of either T-cell type to the development of a particular autoimmune response can influence whether or not this response leads...
RA and T1DM are primarily Th1 cell mediated and that often the shift of the Th1/Th2 balance alleviates these diseases. This is underlined by the fact that T-bet-deficient mice were protected from EAE [81]. Along with this, transfer of myelin-specific Th1 cells induced EAE [82]. However...
但是,T细胞IL-12受体的β2亚单位的表达与Th1细胞效应有比较密切的关系,而GATA-3与Th2细胞效应有比较密切的关系,而在各类肾脏疾病中观察这两种分子的表达有利于判断Th1与Th2平衡,并为相应的干预措施提供监测依据。另外,体外应用细胞因子激活的Th1或Th2细胞,然后转输注体内,也可能成为直接干预Th1或Th2平衡的措施之一...
关键词: 他克莫司;激素抵抗型;肾病综合征;Th1/Th2平衡失调;自身免疫 ABSTRACT ObjectiveTo investigate the effects of tacrolimus on the balance of Th1/Th2 in patients with steroid resistant nephrotic syndrome and its immune effect. MethodsFrom January 2014 to December 2015, 68 patients with steroid resi...
的焦点主要侧重于Thl/Th2细胞平衡紊乱.GD及其他自身 免疫性疾病女性显着高发,提示性激素是影响机体免疫功能 的重要因素.本文就近年来国内外对GD患者Thl/Th2免 疫应答的研究及性激素对Thl/Th2平衡的影响作一综述. 1细胞因子在GD发病中的作用 人类CIMT细胞可分泌多种细胞因子,按生成的细胞 ...
Th1/Th2及Th17/Treg平衡在系统性红斑狼疮患者治疗前后变化的研究摘要背景:系统性红斑狼疮(SLE)是一种由多因素参与的以多脏器受累为特征的自身免疫性疾病,免疫调节功能紊乱贯穿其整个发病过程,具体发病机理仍不明确,无特效的治疗药物,患者病情稳定后无明确的实验室指标指导减药或停药。近年研究认为T淋巴细胞异常并引起...
The Th1/Th2 balance in autoimmunity - ScienceDirect The study of autoimmune disease in the context of T-helper type 1 (Th1) and T-helper type 2 (Th2) CD4+ T-cell responses demonstrates that the relative cont... Brett Charlton a,Kevin J Lafferty b - 《Current Opinion in Immunology》 ...
Furthermore, the high cortisol release on the third stage associated with the increase in the need for seeking medical care during the mid of the semester indicates that participants are exposed to an academic stress that is shifting the Th1/Th2 balance towards Th2. In conclusion, the results...
以Cy5标记的抗CD4、CD8单抗和PE标记的CD30单抗作双色流式细胞术,分析AIHA患者Th/Tc、Th1/Th2、Tc1/Tc2亚群的比例变化。结果:与正常对照组相比,AIHA患者外周血CD4+细胞百分率显着降低(P0.05),CD8+细胞百分率无明显变化(P0.05),CD4+/CD8+比例明显降低(P0.05),CD4+CD30-T、CD4+CD30+T细胞百分率明显下降,CD4...