Th2 cells produce IL-4, which stimulates IgE and IgG1 antibody production, and IL-5, IL-10, and IL-13, which together with IL-4 inhibit macrophage functions. Th1 cells trigger phagocyte-mediated host defense, and infections with intracellular microbes tend to induce Th1-type responses, ...
IL-12 regulation T helper type 1 cytokine responses in human infectious disease. J Immunol, 1994,153:3639-3647. 13 Surcel HM, Troye-Blomberg M, Paulie S, et al. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens...
Author and article information Journal PubMed ID:: 10938051 PMC ID:: 27457 DOI:: 10.1136/bmj.321.7258.424 ScienceOpen disciplines: Chemistry Keywords: Cytokines,immunology,Female,Humans,Hypersensitivity,embryology,Immunity, Cellular,Pregnancy,Th1 Cells,Th2 Cells ...
The immune system's ability to distinguish between self and non-self relies on the intricate regulation of cellular responses to antigens presented by major histocompatibility complex (MHC) molecules to T cells. These responses include those of T helper cells, which can he divided into two populat...
The role of adjuvant on the T(h)1 and T(h)2 immune responses to Abeta-immunotherapy (Abeta(42 )peptide) was examined in wild-type mice. Fine epitope analysis with overlapping oligomers of the Abeta(42) sequence identified the 1-15 region as a dominant B cell epitope. The 6-20 pepti...
Increased expression of the IL-12 p40 gene was negligible in Cry j 2-stimulated cells. Thus, Cry j 1 stimulated mixed features of Th1 and Th2-like responses, while Cry j 2 played a minor role in inducing IgE production and cytokine (IFN-γ, IL-10, and IL-12) production, except for...
Different Th1/Th2 responses to Anisakis simplex are related to distinct clinical manifestations in sensitized patients. Gonzalez-MuNOz, M,Rodriguez-Mahillo, ... M Gonzalez-Mu?Oz,AI Rodriguez-Mahillo,I Moneo - 《Parasite Immunology》 被引量: 31发表: 2010年 Anisakis simplex: dangerous--dead and...
既往认为Th/Th2细胞 失衡是造成哮喘的免疫学发病基础,近年来发现 Th17/调节性T细胞(Treg细胞)失衡在某些类型的 哮喘中可能起重要作用。考虑到Th2细胞在哮喘中 的关键效应和Treg细胞对效应细胞的调控作用, Th2/Treg细胞失衡可能更代表了哮喘的免疫学发病 基础,这对于指导哮喘的治疗无疑具有重要的意义。 哮喘中的Th...
Th1 and Th2 T细胞亚群及Th1/Th2分化的调控机制 授课教师：韩军艳 主要内容 T细胞亚群概述Th1/Th2分化的调控机制 细胞因子转录因子STATTCR信号强弱表观遗传学调控 TCellBehavior MaturationRecognitionActivationApoptosisMemory proliferationDifferentiation Effectorfunctionmigration CD4+T细胞的...
To clarify the predominance of Th1 or Th2 immune responses in malignant and tuberculous pleural effusion (MPE and TPE, respectively), we performed a meta-analysis of previously published results of the levels of Th1/Th2 cytokines associated with these two types of pleural effusion to evaluate the...