2.Tozasertib处理Th-MYCN转基因小鼠结果显示肿瘤生长速度显著降低,且延长了Th-MYCN转基因小鼠的存活时间,肿瘤组织出现坏死的特征,基底膜和组织结构紊乱(图2)。 图2 Tozasertib在Th-MYCN转基因小鼠模型中抑制肿瘤生长。(A)在Th-MYCN转基因小鼠模型中用tozasertib治疗的工作流程的示意图。(B)从第3天到第14天(第...
Kroesen M, Brok IC, Reijnen D, et al. Intra-adrenal murine TH- MYCN neuroblastoma tumors grow more aggressive and exhibit a distinct tumor microenvironment relative to their subcutaneous equivalents [J]. Cancer Immunology, Immunotherapy, 2015,64 ( 5 ) : 563-572....
Purpose: To evaluate noninvasive and clinically translatable magnetic resonance (MR) imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of aggressive, MYCN-amplified neuroblastoma.Materials and Methods: All experiments were performed in accordance with the local ethical review...
TH-MYCN transgenic mouseIVISBackground: Human mesenchymal stem cells (hMSCs) are multipotent stem-like cells that are reported to have tumor-suppression effects and migration ability toward damaged tissues or tumors. The aim of this study was to analyze the tumor-homing ability of hMSCs and ...
Expression of programmed cell death-1 on neuroblastoma cells in TH-MYCN transgenic micedoi:10.1007/s00383-022-05292-yPediatric Surgery International - Immunotherapy may improve the poor prognosis of high-risk neuroblastoma. Programmed cell death-1 (PD-1) is expressed in several cancers. The ...
We revealed that TH-MYCN transgenic mice have a natural antibody against neuroblastoma that correlate with tumor size. However, this antibody does not correlate with the spontaneous regression of neuroblastoma. Thus, the function of the natural antibody is limited....
TH- MYCN transgenic mousePURPOSE:Mesenchymal stem cells (MSCs) are reported to migrate toward damaged tissues or tumors. We previously reported the invivoshort-term (1 day) tumor-homing effect of xenogeneic human MSCs (hMSCs) using the TH-MYCN mouse neuroblastoma model (MYCN-TgM). In this ...
Translatable MR Imaging Biomarkers of Therapeutic Response in the TH- MYCNTucker, Elizabeth RVaughan, LynseyBoult, Jessica K RWebber, HannahHallsworth, AlbertJones, ChrisPearson, Andrew D JRobinson, Simon P
The aim of this study was to analyze the tumor-homing ability of hMSCs and antitumor potency in a transgenic TH-MYCN mouse model of neuroblastoma (NB).关键词:Neuroblastoma Mesenchymal stem cell Homing TH-MYCN transgenic mouse IVIS 年份: 2016 ...
Abstract 4189: Characterization of tumor progression and chemoresponse in a novel transgenic mouse model of neuroblastoma (TH-MYCN) using magnetic resonance imaging Neuroblastoma is the most common extracranial childhood solid tumour, accounting for between 7-10% of paediatric cancers, and originates in...