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Th22 cells are a newly discovered class of CD4+ T cells that play important roles in inflammatory, autoimmune and infectious diseases. However, it is unclear whether Th22 cells are involved in the pathogenesis of DE. Methods We established a T2DM mouse model in vivo and cocultured Th22 ...
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(e.g., lymph nodes and spleen), where they are activated by antigens presented by APCs. This activation involves interactions between MHC class II and co-stimulatory molecules on APCs with TCR and CD28 on T cells, leading to their differentiation into various Th cell subtypes based on ...
class II complexes were biotinylated in a BirA sequence (DRB chain) using a BirA ligase (Avidity). The Biot-peptide-HLA class II complexes were then used to generate tetramers using Streptavidin-PE. Tetrameric complexes were finally separated by gel filtration and stored in PBS + NaAz (...
TCF-1 and LEF-1 are essential for early T cell development. Xue and colleagues show that in DP thymocytes, they control CD4+-versus-CD8+ T cell lineage 'decisions' and contribute to the establishment of CD8+ T cell identity. The transcription factors TCF
Henley Passport Index accesses where a passport ranks on the global mobility spectrum. Get the key findings of the Index and the Global Passport Ranking 2021. Download notes PDF for UPSC 2022 preparation
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