Objective-The immunosuppressive properties of azathioprine (AZA) are mediated by intracellular metabolism of 6-MP into its active metabolites 6-thiguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP). The aims of this study were to correlate red blood cell (RBC) 6-TGN and hematological...
present a patient with ulcerative colitis who was unresponsive to therapy with thiopurines and had both a high TPMT activity and an unfavorable ratio of thiopurine metabolites, i.e., a high concentration of methylmercaptopurine nucleotides (MMPNs) [2] relative to thioguanine nucleotides (TGNs). Po...
Sign in to download full-size image Fig. 14.3.Chemical structures of the Bial FAAH inhibitor, one of its metabolites, Pfizer’s FAAH inhibitor, and anandamide. We encouraged first edition readers who were not familiar with this story to look up what really happened and suggested they compare t...
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The water channel aquaporin-4 (AQP-4) plays a very important role in the mechanisms involved in water homeostasis in the brain and also participates in the clearance of brain parenchyma from various metabolites, including amyloidogenic proteins that contribute to the development of neurodegenerative ...
The immunosuppressive properties of azathioprine (AZA) are mediated by intracellular metabolism of 6-MP into its active metabolites 6-thiguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP). The aims of this study were to correlate red blood cell (RBC) 6-TGN and hematological ...
Methylated thiopurine metabolites (MeMPs) formed via thiopurine-S-methyltransferase (TPMT) may also have immunosuppressive properties through inhibition of de novo purine synthesis (DNPS). Individuals with intermediate TPMT activity do not produce significant levels of methylated metabolites, with predictably...
Maternal thiopurine metabolism during pregnancy in inflammatory bowel disease and clearance of thiopurine metabolites and outcomes in exposed neonates. Aliment Pharmacol Ther. 2021;53:810-820. 2.Jharap B, De Boer NKH, Stokkers P, et al. Intrauterine exposure and pharmacology of conventional ...