In conclusion, the results suggested that SB inhibits CRC cell metastasis via the suppression of PI3K/AKT and TGF-beta/Smad signaling pathways, which may represent a mechanism by which SB exerts an anticancer effect.doi:10.3892/etm.2017.5242Jin, YiyiChen, WujinYang, HongYan, ZhaokunLai, Zi...
TGF-beta activation of Smad3 is mediated through TbetaRI. TGF-beta also activates PI3K/Akt/mTOR signaling pathway. TGF-beta increases PI3K activity by &sim2.3- and 2.5-fold in the 10A and 10AT cells, with no TGF-beta response in the CA1h and CA1a cells. TGF-beta increases Akt ...
内皮素激活PI3KAkt信号通路对恶性黑省略活性及TGFbeta1表达调,内皮素激活PI3KAkt信号通路对恶性黑省略活性及TGFbeta1表达调,核桃内皮的功效与作用,内皮细胞,血管内..
Furthermore, the PI3K antagonist, LY294002, reduced TGF-beta1-stimulated COL1A2 promoter activity and Racl activation. It also partially blocked active Rac 1-stimulated collagen promoter activity, suggesting that PI3K activity contributes to both TGF-beta activation of Racl and signal propagation ...
TNFalpha, PDGF, and TGFbeta syn- ergistically induce synovial lining hyperplasia via inducible PI3Kdelta. Mod Rheumatol 2015; 25: 72-78.Shibuya H1, Yoshitomi H, Murata K, et al. TNFα, PDGF, and TGFβ synergistically induce synovial lining hyperplasia via inducible PI3Kδ[ J]. Mod ...
TGF-beta induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways. J Cell Physiol 217: 759 -768, 2008.Tacheau C , Fontaine J , Loy J , Mauviel A , Verrecchia F ( 2008 ). TGF-beta induces connexin43 gene ...
Yao, K,Ye, PP,Tan, J, et al.Involvement of PI3K/Akt pathway in TGF-beta 2-Mediated epithelial mesenchymal transition in human lens epithelial cells. Ophthalmic Research . 2008Yao K,Ye P P,Tan J,et al.Involvement of PI3K/Aktpathw ay in TGF-beta2-mediated epithelial mesenchymaltran...
PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-beta 1 signaling to PI3K gamma/AKT/Rac1 pathwayPHP14Hepatic stellate cellMigrationPI3K gamma/AKT/Rac1 pathwayLiver fibrosisHepatic fibrosis is characterized by the activatioJournal of molecular medicine: Official organ ...
SDF-1 Improves Renal Fibrosis in Type 2 Diabetes Mellitus Involving TGF-beta-mediated ECM via PI3K/AKT SignalingJ. XieJi ZhangH. Shuai
Furthermore, maltol significantly suppressed the transforming growth factor-beta 1 (TGF-beta 1) expression and the PI3K/Akt pathway. This study suggested that maltol alleviated experimental liver fibrosis by suppressing the activation of HSCs and inducing apoptosis of activated HSCs through TGF-beta 1...