Elevated levels of tumor necrosis factor-alpha (TNFα) that significantly contribute to MMP9 production were observed during CL [7]. By contrast, convalescence is associated with Th1 cytokines, primarily IL-2 and IFN-γ. IL-12 is a predominant factor that stimulates NK cells to produce IFN-...
Expression of TGF-β1, SNAI1 and MMP-9 is associated with lymph node metastasis in papillary thyroid carcinoma. J Mol Histol. 2014; 45:391-399. https://doi.org/10.1007/s10735-013-9557-9 PMid:24276590Wang N, Jiang R, Yang JY, Tang C, Yang L, et al. (2014)...
creates a large latent complex that may interact with the extracellular matrix (5-7). TGF-beta activation from latency is controlled both spatially and temporally, by multiple pathways that include actions of proteases such as plasmin and MMP9, and/or by thrombospondin 1 or selected integrins (...
large latent complex that may interact with the extracellular matrix (5‑7). TGF-beta activation from latency is controlled both spatially and temporally, by multiple pathways that include actions of proteases such as plasmin and MMP9, and/or by thrombospondin 1 or selected integrins (5, 8)....
A previous study demonstrated that short-term peaks in glucose increased the production of collagen type IV, fibronectin, MMP2, MMP9, and TGF-1 in human renal cortical fibroblasts [17]. Thus, they concluded that exposure to fluctuating glucose concentrations increases renal interstitial fibrosis in...
Cartilage degeneration, characterized by progressive loss of aggrecan and Type II collagen, had been previously considered to be the central pathological feature of OA. Elevated expression levels of multiple MMPs, such as MMP2, MMP9, and MMP13, are involved in this degenerative process.151In recen...
Co-culture of activating tumour cells with fibroblasts resulted in induction of transcripts associated with tumour cell invasion and growth, TGF beta 1 and TGFBR1, SERPINE-1, BMP6, SPHK1 and MMP9. Fibroblast activation was inhibited by an alpha v beta 6/8 integrin blocking antibody (264RAD)...
(G) MMP1–MMP9 mRNA levels upon ITGB3 expression. (H and I) Normal BFs were treated with conditioned media (CM) from BFs expressing vector or ITGB3. (H) Pan-specific neutralizing anti-TGF-β1-3 antibodies inhibit the stabilization of p53 induced by the CM taken from ITGB3 cells. ...
ACEI attenuates the progression of CCl4-induced rat hepatic fibrogenesis by inhibiting TGF-β1, PDGF-BB, NF-κB and MMP-2,9 AIM: Angiotensin Ⅱ has pro-fibrotic function in the liver.Blockade of the renin-angiotensin-aldosterone-system (RAAS) attenuates hepatic fibrosis. The aim... Xu Li Yi...
Besides, miRNA-146a overexpression also decreased the messenger RNA (mRNA) and protein expression of epidermal growth factor receptor (EGFR) and MMP9 as well as the p-ERK1/2 level. Furthermore, the upregulation of miRNA-146a suppressed TGF-beta 1-mediated U87 proliferation and migration. These...