TGF-β 在肿瘤发展中具有双重作用，它可以通过调节免疫系统和肿瘤微环境来促进肿瘤细胞的侵袭和转移。在恶性早期，肿瘤或基质细胞分泌的 TGF-β 通过诱导细胞周期阻滞和促进细胞凋亡发挥抑癌作用。TGF-β 通过调节细胞周期蛋白依赖性激酶 (CDK) 抑制剂 p21 和 c-Myc 的表达来抑制细胞周期进程，导致 G1 晚期周期停...
肿瘤信号传递转化生长因子βEpithelial and hematopoietic cells have a high turnover and their progenitor cells divide continuously, making them prime targets for genetic and epigenetic changes that lead to cell transformation and tumorigenesis. The consequent changes in cell behavior and responsiveness result...
Alantolactone 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。 ApoptosisSTATTGF-beta/Smad ¥ 194 现货 规格 数量 客户已引用 "SRI-011381"的相关化合物库 神经保护化合物库 Neuroprotective Compound Library L2640990 化合物 产品详情 ...
基因表达谱芯片结果显示, 经GMA诱导16HBE细胞恶性转化后期差异表达基因通路涉及TGF.8信号系统(TGF-betasignalingpathway-Homosapiens(human)),其已被揭示与多种人类肿瘤相关,且其改变也与肿 瘤的发展和预后密切相关。1。 TGF-IB(transforminggrowthfactorbeta,转化生长因子6)是一种多功能的多肽类细胞 因子。TGF能够...
Mechanisms of resistance to TGF-beta caused by modulation of cell cycle regulators and/or inactivation of components of the TGF-beta signaling transduction pathway such as C-myc and Smad4 have been demonstrated in human pancreatic cancer and squamous cell carcinoma cell lines. But, this has not ...
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease. 体外活性 SRI-11381具有神经保护作用。研究表明,SRI-011381通过促进巨噬细胞清除纤维状Aβ,从而体现其功效,这一作用在于观察到处理过的巨噬细胞培养基中Aβ含量的剂量依赖性...
近日,美国《生物化学杂志》(Journal of Biological Chemistry)在线发表了中科院上海生命科学研究院营养科学研究所陈雁研究组的最新研究成果Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-beta signaling pathway。该研究发现一个接头蛋白Tollip能与Smad7协同作用,影响...
The effects of transforming growth factor betal/Smads signaling pathway changes on the pathogenesis of liver fibrosis; 转化生长因子β1/Smads信号转导通路的变化在肝炎肝硬化发生中的作用 3. Expression of transforming growth factor beta-1 and insulin like growth factor-1 receptor in human uterine leiomy...
Use of TGF-beta stimulating agents, in particular, members of the triphenylethylene class of pharmaceutical agents, for the prevention, prophylaxis, treatment or amelioration of symptoms of cardiovascular disease, autoimmune diseases or neurodegeneration. In particular, compositions consisting the said triphe...
Transforming Growth Factor beta肿瘤坏死因子转化生长因子βThe vascular endothelium participates in angiogenesis, inflammation and the immune response, which are ... C Li,B Guo,S Ding,... - 《Anticancer Research》 被引量: 81发表: 2003年 Regulation of adhesion and growth of fibrosarcoma cells by ...