Cellular biology The role of TGF-beta and Wnt5a in mammary gland development and tumorigenesis THE UNIVERSITY OF ALABAMA AT BIRMINGHAM Rosa A. Serra RoartyKevin PatrickBreast cancer is the second most common cancer worldwide behind lung cancer, affecting women of all ages, races, ethnicities, ...
这些结果表明,丹参及丹参茎叶通过抑制wnt/β-catenin和TGF-β信号通路对II型糖尿病早期肾病大鼠具有保护作用。 本研究获得的TGF-β检测结果可能导致花生四烯酸代谢紊乱。结果表明,丹参提取物可改善肾损伤,调节糖脂代谢异常。血清、尿、肾组...
TRANSFORMING growth factors-betaDiscusses the regulation of both cell fate and proliferation during development and tissue maintenance by members of the Wnt and TGF-beta superfamilies. Requirement of the Wnt and TGF-beta superfamily signalling cascades for the establishment of a dorsal signalling ce...
Near the anterior limit of the abdA domain, two signals, Dpp (a TGFbeta) and Wg (a Wnt), are produced, in adjacent non-overlapping patterns, under Hox control in mesoderm cells. The two signals are known to regulate local mesodermal cell fates and to signal to the endoderm. We find ...
SMAD2, SMAD3 and TGF-beta GENE expressions in women suffering from urge urinary incontinence and pelvic organ prolapse We evaluated the changes in the levels of TGF-beta and SMAD gene and protein expression in the uterosacral ligament (USL) of patients with concomitant pelv... Akin, Melike Nu...
TGF-β signaling pathway (Table1), as well as the Wnt signaling components Wnt11, Fzd1/7 and Notum as putative candidates for a regulatory function. To further investigate the dependence of Wnt components on FoxO and insulin signaling we performed an expression analysis of selected Wnt pathway ...
et al. Bulk cell density and Wnt/TGFbeta signaling regulate mesendodermal patterning of human pluripotent stem cells. Nat. Commun. 7, 13602 doi: 10.1038/ncomms13602 (2016). Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional...
Signaling proteins in the wingless-type mouse mammary tumor virus (MMTV) integration site family (Wnt), Sonic hedgehog (SHH), and transforming growth factor beta (TGF beta) pathways may regulate cell proliferation, migration, and apoptosis. Accordingly, the genes encoding these signaling proteins ...
The transforming growth factor-beta (TGF-beta) signalling pathway is a key mediator of fibroblastactivation that drives the aberrant synthesis of extracellular matrix in fibrotic diseases. Herewe demonstrate a novel link between transforming growth factor-beta and the canonical Wntpathway. TGF-beta stim...
73 SYNOVIAL OVEREXPRESSION OF WNTS AND WISP1 LEADS TO OA-LIKE CARTILAGE DAMAGE AND CHONDROCYTE PHENOTYPE CHANGE BY SKEWED TGF-BETA SIGNALING Author links open overlay panelM.H. van den Bosch, A.B. Blom, P.L. van Lent, H.M. van Beuningen, F.A. van de Loo, E.N. Blaney Davidson, ...