Meanwhile, TGF beta 1 enhances the expression of COL4A2, COL5A1, COL7A1, COL1A1, COL2A1, and alpha-SMA, hinting that TGF-beta 1 possesses the potential to drive HSG fibrosis-related events. Besides, TGF-beta 1 also attenuates the AQP5 expression and its membrane distribution in HSGs. ...
食管特定正常黏膜蛋白1(NMES1)重组蛋白 N-乙酰硫酸酯酶(GALNS)重组蛋白 叉头框蛋白M1(FOXM1)重组蛋白 钠氢交换调控因子2(SLC9A3R2)重组蛋白 钠/钾离子转运ATP酶α1肽(ATP1a1)重组蛋白 滋养层特异性糖蛋白(5T4)重组蛋白 蛋白激酶D1(PKD1)重组蛋白 Ⅰ型胶原(COL1)天然蛋白 甲状腺素受体β(THRb...
The role of members of the mitogen-activated protein kinase (MAPK) family on tumor necrosis factor α (TNF-α)-mediated down-regulation of col1a1 gene was ... M Varela-Rey,C Montiel-Duarte,JA Osés-Prieto,... - 《Febs Letters》 被引量: 224发表: 2002年 Smad and p38 MAP kinase-medi...
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However, Il-6 deficiency did not affect the pathological fibrosis (Fig. A. 7A-B) and the protein levels of Col1a1 and Col3a1 in the lung tissues of 12 weeks silicosis mouse models (Fig. A. 7C-E). Numerous studies have suggested that the Tgf-β1/Smad2/3 signaling pathway is activat...
TEM was used to confirm the presence of BMSC-EVs (Fig.1A), while their diameter of BMSC-EVS was detected by dynamic light scattering (Fig.1C). The markers of BMSC-EVs were analyzed using western-bloting (Fig.1B). Fig. 1 BMSC-EVs upregulate the expression of Smad 6 in NSCs.A.Identi...
BMP1 BMP3 BMP4 BMP5 BMP6 BMP7 BMPER BMPR1A BMPR1B BMPR2 CDKN1A CDKN1B CDKN2B CHRD COL1A1 COL1A2 DCN DLX2 EMP1 FOS FST GADD45B GDF2 GDF3 GDF5 GDF6 GDF7 GSC HERPUD1 GDF6HIPK2 ID1 ID2 IFRD1 IGF1 IGFBP3 IL6 INHA INHBA INHBB LEFTY1 LTBP1 LTBP2 Fold change (FRS2α ...
The TGF-[beta] activator protein is a transacting factor, which binds to the TGF-[beta] element in the distal promoter of the COL1A1 collagen gene and induces transcription of this gene. Although transient TGF-[beta]1 activity participates in repair and re...
A novel nonsteroidal antifibrotic oligo decoy containing the TGF-beta element found in the COL1 A1 gene which regulates murine schistosomiasis liver fihrosis[J].J Cell Physiol, 2005, 204(2):370-374.Boros DL,Singh KP,Gerard HC,et al.A novel nonsteroidal antifibrotic oligo decoy containing ...
Furthermore, overexpression of miR-29b markedly reduced the expression levels of COL1A1 and alpha-SMA, and decreased the expression and nuclear accumulation of p-Smad2/3. In addition, ectopic overexpression of miR-29b increased the expression levels of MEG3, inhibited myofibroblast-like cell ...