alpha-SMA+ cells clustered with macrophages into the interstitium. These changes were associated with appearance of transforming growth factor-beta1 (TGF-beta1) mRNA in proximal tubular cells and in the infiltrating cells with time. At day 30, focal alpha-SMA staining also was found in the ...
Immunofluorescenceα-SMASMAD4 / SMAD2 / SMAD3F-actin / β-catenin / Vimentin 22132230 In Vivo In vivo Pirfenidone (250 mg/kg) potently inhibits the production of the proinflammatory cytokines, TNF-alpha, interferon-gamma, and interleukin-6, but enhances the production of the anti-inflammatory cy...
For instance, the polynucleotide can be introduced into the one or more cells by contacting the one or more cells with a viral vector, such as a retrovirus, adenovirus, adenoassociated virus, parvovirus, coronavirus, rhabdovirus, paramyxovirus, picornavirus, alphavirus, herpes virus, or poxvirus, ...
University of Groningen alpha II-spectrin and beta II-spectrin do not affect TGF beta 1-induced myofibroblast differentiation Piersma, 来自 Semantic Scholar 喜欢 0 阅读量: 20 作者:B Piersma,OY Wouters,R Bank 摘要: Mechanosensing of fibroblasts plays a key role in the development of fibrosis. ...
adaptorFrs2α(fibroblast growth factor receptor substrate 2 alpha) in mice profoundly reduces neointima formation and vascular remodelling following carotid artery ligation. These results demonstrate that FGF-TGFβsignaling antagonism is the primary regulator of the SMC phenotype switch. Manipulation of ...
(Paired-like homeodomain transcription factor 2) axis, impairs ventral musculature formation and leads to ventral body wall closure defects38. Similarly, disruption of epithelial transcription factor AP-2 alpha (AP2α), aortic caroboxy-peptidase like protein (ACLP) and other components of the Wnt ...
Functional studies have demonstrated that a host erythrocyte G protein signal pathway may be a critical component in parasite invasion and that erythrocyte G-alpha-s protein and the malaria parasite interact at a cellular level [53]. It however remains unclear whether this interaction would impact ...
23. Achidi EA, Apinjoh TO, Yafi CN, Besingi R, Anchang JK, Awah NW, Troye- Blomberg M: Plasma levels of tumour necrosis factor-alpha, interleukin-10, interleukin-12, macrophage inhibition factor and transforming growth factor-beta in children with severe and uncomplicated falciparum malaria....
The expression of collagen I, alpha-SMA, and TGF-beta 1/Smad/CTGF pathway proteins were analyzed by qRT-PCR and/or western blot analysis. The cell proliferation rate was determined by CCK-8 assay. The results indicated that pirfenidone significantly attenuated fibrotic lesion in irradiated ...