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Cell fate decisions are not determined simply by the available nutrients in the surrounding environment but controlled by a network of communication signals. TGF-β1, 2 and 3 are evolutionarily conserved, secreted, isoforms that are encoded as large protein precursors with 70–80% homology that ...
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133, 1106–1117 (2008). Article CAS PubMed Google Scholar Ying, Q. L., Nichols, J., Chambers, I. & Smith, A. BMP induction of Id proteins suppresses differentiation and sustains ...
Dermal lymphatic endothelial cells (LECs) emerge from the dorsolateral region of the cardinal veins within the anterior trunk to form an intricate, branched network of lymphatic vessels during embryogenesis. Multiple growth factors and receptors are required for specification and maintenance of LECs, but...
Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis 【摘要】(阅读原文为主) 背景和目的 天麻素作为一种抗高血压药物在中国临床上得到广泛应用。然而,其对高血压肾损伤的影响尚待阐明。本研究旨在通过网络药理...
LAP in turn is cleaved from the mature TGFβ precursor in the trans-golgi network but LAP and TGFβ remain strongly bound through non-covalent interactions. LAP, TGFβ, and LTBP together form the large latent complex (LLC). LTBPs were originally thought to primarily play a role in ...
TGF-β1 targets a microRNA network that regulates cellular adhesion and migration in renal cancer - ScienceDirectRenal cancer J Bogusawska,K Rodzik,P Popawski,... 被引量: 0发表: 0年 TGF-beta 1 targets a microRNA network that regulates cellular adhesion and migration in renal cancer TGF-...
within a network of profibrotic and antifibrotic cyto- kines and secreted proteins. These proteins include profibrotic proteins transforming growth factor- (TGF- ) and connective tissue growth factor (CTGF) and the antifibrotic proteins tumor necrosis factor- ...
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