转化生长因子 β (TGF- beta) 超家族是最大的分泌性生长因子家族,它由几个亚家族组成,包括 TGF-βs、骨形态发生蛋白 (BMPs)、生长和分化因子 (GDFs)、激活素、抑制素和神经胶质细胞衍生的神经营养因子 (GDNFs)。 TGF-β 信号传导是通过配体结合由 I 型和 II 型跨膜丝氨酸/苏氨酸激酶受体组成的异聚体...
TGF-beta 1 (Transforming growth factor beta 1), is a polypeptide member of theTGF-betasuperfamily ofcytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-beta is encod...
TGF-beta Superfamily Intracellular Signaling Molecules Featured Products for TGF-beta Superfamily Research Preclinical Animal-Free™ and GMP-grade Recombinant Proteins To simplify the transition from basic research to preclinical applications andex vivocell manufacturing, we offer research-grade, preclinical ...
转化生长因子 β (TGF- beta) 超家族是最大的分泌性生长因子家族,它由几个亚家族组成,包括 TGF-βs、骨形态发生蛋白 (BMPs)、生长和分化因子 (GDFs)、激活素、抑制素和神经胶质细胞衍生的神经营养因子 (GDNFs)。 TGF-β 信号传导是通过配体结合由 I 型和 II 型跨膜丝氨酸/苏氨酸激酶受体组成的异聚体复合...
[11] Wrighton,K. H., et al. (2009). Phospho-control of TGF-beta superfamily signaling. CellRes 19, 8-20. [12] Conery,A. R., et al. (2004). Akt interacts directly with Smad3 to regulate thesensitivity to TGF-beta induced apoptosis. Nat Cell Biol 6, 366-72. ...
[11] Wrighton,K. H., et al. (2009). Phospho-control of TGF-beta superfamily signaling. CellRes 19, 8-20. [12] Conery,A. R., et al. (2004). Akt interacts directly with Smad3 to regulate thesensitivity to TGF-beta induced apoptosis. Nat Cell Biol 6, 366-72. ...
[11] Wrighton,K. H., et al. (2009). Phospho-control of TGF-beta superfamily signaling. CellRes 19, 8-20. [12] Conery,A. R., et al. (2004). Akt interacts directly with Smad3 to regulate thesensitivity to TGF-be...
TGFbeta superfamily signaling is essential for the heart developmentMolecular biology TGFbeta superfamily signaling is essential for the heart development UNIVERSITY OF SOUTHERN CALIFORNIA Vesa Kaartinen SridurongritSomyothTransforming growth factor betas (Tgf尾s) and Bone morphogenetic proteins (Bmps) are...
, a TGF-beta superfamily type I serine / threonine kinase receptor extracellular domain, a TGF-beta superfamily type II serine / Provided are heteromeric polypeptide complexes comprising the extracellular domain of a threonine kinase receptor, or an additional co-receptor of the TGF-beta superfamily....
TGF-beta superfamily receptors signal through cell-surface serine/threonine kinase receptors to the intracellular Smad proteins, which in turn accumulate in the nucleus to regulate gene expression. TGF-beta superfamily, found in both vertebrates and invertebrates, are ubiquitously expressed in diverse tiss...