[15].Herbertz S, Sawyer JS, Stauber AJ, Gueorguieva I, Driscoll KE, Estrem ST, et al. Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta sig...
TGF-β配体和细胞膜上的TGFBR2结合,一旦结合TGFBR2磷酸化并激活TGFBR1;活化的TGFBR1依次磷酸化并激活受体活化的SMADs(R-SMADs:SMAD2和SMAD3);SMAD7和R-SMADs竞争与TGFBR1相互作用,从而阻止R-SMAD的激活和信号的正常传导。 激活的R-SMADs与TGFBR1分离,从而与通用SMAD...
转化生长因子-β（Transforming growth factor-beta，TGF-β）是一种相对分子质量为25-kDa的二聚体蛋白，由两个亚基组成，是一种多功能细胞因子，属于转化生长因子超家族。转化生长因子超家族包括骨形态发生蛋白（BMPs）、生长分化因子（GDFs）、胶质源性神经营养因子（GDNFs）、激活素、抑制素等各种各样的蛋白质家族...
11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230.12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med. 2000; 342(2):69-77.13. Papageorgis P, Stylianopoulos T. Role of ...
The purity of Human LRRC32 & TGF-beta 1, His Tag (Cat. No. GA1-M52W2) is greater than 95% verified by SDS-PAGE and more than 90% verified by SEC-HPLC. Integrin高批间一致性验证 Immobilized Human Fibronectin at 2 μg/mL (100 μL/well) can bind Human ITGAV&ITGB1 Heterodimer Prot...
产品名称:Rabbit Anti-TGF Beta R1 Polyclonal Antibody 产品别名:TGF β R1抗体 宿主:Rabbit 反应种属:Human;Mouse;Rat; 克隆性:Polyclonal Antibody 保存方法:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 产品描述: 用途范围:WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500...
1.Massagué J. TGFbeta in Cancer.Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001. PMID:18662538; PMCID: PMC3512574. 2.Vander Ark A, et al. TGF-βreceptors: In and beyond TGF-β signaling. Cell Signal. 2018 Dec;52:112-120.doi: 10.1016/j.cellsig.2018.09.002...
英文名称: ELISA Kit for Transforming Growth Factor Beta Receptor I (TGFbR1) 分子式: 电询 纯度: 99 % 产地: 中国/美国/德国 品牌: BioLegend,Cygnus,IBL,TSZ等国内外品牌 包装规格: 96T/48T 货号: XYA397Mu 别名: 电询 小鼠转化生长因子β受体Ⅰ(TGFβR1)检测试剂盒包被原的性质很重要,蛋...
英文名称:ELISA Kit for Transforming Growth Factor Beta Reklptor I (TGFbR1) 规格:96T/48T 品牌:美国eBioscience公司德国IBL美国BD瑞士ALEXIS等进口品牌。 种属:人 检测波长:450 nm 所需样本的体积:50-100ul 适用范围:仅供科研使用 保存及有效期:2-8℃保存,6个月,-20℃一年 ...
Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139.11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230.12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J ...