The levels of insoluble Aβ and fibrillar amyloid were significantly reduced in bigenic Tg-5xFAD/Tg-MBP1-EGFP mice. Quantitative stereological analysis revealed that the reduction in amyloid was because of a reduction in the size of fibrillar plaques rather than a decrease in plaque numbers. The...
Tg-MBP1-EGFP/Tg-5xFAD mice, we observed improved spatial memory performance accompanied by a reduction in fibrillar am- yloid. These findings indicate that MBP1, even at relatively low levels, reduced fibrillar Ab pathology and improved cognitive per- ...