Here, we show that the modest neuronal expression of a fusion protein of the biologically active MBP1 fragment and the enhanced green fluorescent protein (MBP1-EGFP) significantly improved the performance of spatial learning memory in Tg-5xFAD mice, a model of pathologic Aβ accumulation in ...
Tg-MBP1-EGFP/Tg-5xFAD mice, we observed improved spatial memory performance accompanied by a reduction in fibrillar am- yloid. These findings indicate that MBP1, even at relatively low levels, reduced fibrillar Ab pathology and improved cognitive per- ...