T cellsT helper cellsINTERLEUKIN-17CELL physiologyANTIBODY formationCD4T cells mediate rheumatoid arthritis (RA) pathogenesis through both antibody-dependent and independent mechanisms. It remains unclear how synovial microenvironment impinges on CD4T cells pathogenic functions. Here, we identified a TLR4...
10.Costantino AB, Acosta CDV, Onetti L, Mussano E, Cadile II, Ferrero PV. Follicular helper T cells in peripheral blood of patients with rheumatoid arthritis.Reumatol Clin. 2017;13:338-343.[PubMed][DOI] 11.Zhang CJ, Gong Y, Zhu W, Qi Y, Yang CS, Fu Y, Chang G, Li Y, Shi S...
Next, we checked the effect of ethanol on TFHcells, which are vital for induction of antibody production by B cells at the T-B interaction sites in the GC19. TFHcell numbers were decreased already at 4 dpi in ethanol-exposed CIA mice, however, this difference faded following the 2ndCII c...
Tfh cells induce B cells differentiation and promote immunoglobulin secretion by IL-21 secretion. During SSc, cTfh cells impairment is associated with an imbalance of B cell subsets [25,35]. Frequencies of both naïve B cells and plasmablasts are increased while the frequency of memory B cells...
CXCR5−CD4+ICOS+CD40L+T cells named T peripheral helper (Tph) cell are also able to help B cells and have been observed in inflamed tissue in autoimmune diseases [17]. Tph cells seem to be increased in systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) peripheral blood [18]...
Several studies have demonstrated that an imbalance in the ratio of Tfr/Tfh cells may result in the excessive production of self-reactive autoantibodies, thereby promoting the occurrence of autoimmune disorders such as systemic lupus erythematosus(SLE) and rheumatoid arthritis (RA) and myasthenia gravis...
Conversely, follicular regulatory T cells (TFR), derived from peripheral T regulatory cells (Treg), suppress the TFH and B cell interactions within the GC, thereby sustained immune response activation [7]. Recent studies have shown that TFH/TFR balance is a determining factor in the pathogenesis...
Objectives Rheumatoid Arthritis (RA) is an autoimmune disease characterized by the presence of autoantibodies and chronic inflammation in synovium leading to joint destruction. Recently Tfh and Th17 cells have emerged as novel T cell subsets controlling autoimmunity. Our previous data showed that ...
Background Rheumatoidarthritis (RA) is an inflammatory autoimmune disease characterized by T cell infiltration in the joints and autoantibody production. T follicular helper (Tfh) cells are a unique subset of CD4+ T cells regulating antibody production in B cell follicle. Our previous studies have ...
The aim of this study was to determine the regulation of oxymatrine on rheumatoid arthritis using a collagen‐induced arthritis (CIA) mice models and blood samples from RA patients. Results Our results indicated that Tfr cells in RA patients express low levels of Blimp‐1 and CTLA‐4. ...