本发明公开一种覆盖TFPEGPLGA涂层的载药ZIF8纳米粒及其制备方法与应用,所述包括:将目标药物,2甲基咪唑,硝酸锌加入甲醇溶液中混合进行第一反应,后纯化溶于甲醇,获得载药ZIF8纳米粒溶液;将COOHPEGPLGA活化后与转铁蛋白在PBS中混匀进行第二反应,后纯化溶于PBS,获得转铁蛋白修饰的PEGPLGA溶液;将所述载药ZIF8纳米粒...
本发明公开一种覆盖TF‑PEG‑PLGA涂层的载药ZIF‑8纳米粒及其制备方法与应用,所述包括:将目标药物、2‑甲基咪唑、硝酸锌加入甲醇溶液中混合进行第一反应,后纯化溶于甲醇,获得载药ZIF‑8纳米粒溶液;将COOH‑PEG‑PLGA活化后与转铁蛋白在PBS中混匀进行第二反应,后纯化溶于PBS,获得转铁蛋白修饰的PEG‑...
We further detected the levels of HIF-1伪, Bcl-2, Bax and Caspase-3 of K562 cells in transcription and protein under hypoxia regulated by DNR, DNR-PEG-PLL-PLGA and DNR-Tf-PEG-PLL-PLGA, respectively. DNR-Tf-PEG-PLL-PLGA had the best effect when compared with other groups. Furthermore...
Methods: The pharmacokinetics and tissue distribution of DNR/Tet-PLGA-PLL-PEG-NPs-Tf (D/T-PPP-NPs-Tf), DNR/Tet-PLGA-PLL-PEG-NPs (D/T-PPP-NPs) and DNR/Tet (Da) solution were compared following intravenous injection in the rats. Result: Compare to D/T solution, the parameters of DNR...