CAR-T,即Chimeric antigen receptor T cell,直译过来是嵌合抗原受体T细胞,是一种经过人工改造的基因工程化T细胞。可以理解为人为的给正常T细胞加入(嵌合)特定抗原的受体,使T细胞行使特异杀伤功能。 Davila ML, Bouhassira DC, Park JH...
Treatment of membrane receptors with glycosidases prior to lectin probing, revealed that fucosylated Thomsen鈥揊riedenreich(TF) antigen glycans are increasingly expressed on transformed Molt-4 leukemic cells compared to other cells. The findings highlight the opposite effects of SRL on transformed and ...
Overexpression of BATF in CD8+ T cells expressing a chimeric antigen receptor (CAR) promoted the survival and expansion of tumor-infiltrating CAR T cells, increased the production of effector cytokines, decreased the expression of inhibitory receptors and the exhaustion-associated transcription factor ...
PS2/TFF1基因又称乳腺癌雌激素诱导基因, 于1982年首次从乳腺癌细胞系MCF-7中提取并测序鉴定. 其编码的pS2蛋白和猪解痉多肽(SP)、小肠三叶因子(ITF)含有相同的三叶草结构域(TFF), 他们共同组成了三叶因子家族. 正常情况下PS2/TFF1仅在成人胃组织中表达, 胃底、胃窦和幽门腺的黏膜内均表达PS2/TFF1, 主要定位于...
BMC Research Notes 2012, 5:694 http://www.biomedcentral.com/1756-0500/5/694 SHORT REPORT Open Access Expression of antigen tf and galectin-3 in fibroadenoma Itandehui Belem Gallegos1, Eduardo Pérez-Campos2, Margarito Martinez2, Miguel Ángel Mayoral1, Laura Pérez1, Sergio Aguilar1, Edgar...
Following the citrate/EDTA antigen retrieval method (Absin, China), the tissues were subjected to staining using an IHC detection kit (ZSGB-Bio, China). Two skilled pathologists evaluated the same IHC images. Positive staining was indicated by brownish yellow granules on the cell nucleus and/or ...
(DAD1) U83628 HR21spA D49429 D Transcription factors DNA-binding proteins Ets-related protein PEA 3 Nucleobindin X63190 M96823 E Receptors Cell surface antigen & cell adhesion CD44 antigen CD14 monocyte differentiation antigen precursor M27129 M34510 F Cell-cell communication Endothelial ligand ...
B cells play a critical role in autoimmune diseases such as SLE and pSS, where their function is regulated by cytokines secreted by Tfh cells [123]. These cytokines stimulate B cell proliferation and the production of antibodies that target self-antigens [124,125,126]. The transcription factor...
Fifteen μm slices from cryopreserved optimal cutting temperature (OCT)-embedded paraformaldehyde-fixed mice brains were obtained and collected onto poly-L-lysine-coated glass slides, exposed to antigen retrieval (95-99º C in 0.01 mol/L citrate buffer, pH 6.0, for 20 min), and incubated over...
Molecular Nutrition & Food Research Trans‐fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll‐like receptors PubMed: 25546502 Food Funct The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H...