We evaluated the effects of the clinical-used beta-adrenoceptor antagonists, propranolol, esmolol and landiolol, and then compared with the effect of lidocaine, on TTX-r Na+ channels in rat dorsal root ganglion neurons by the whole-cell patch clump method. Methods:Experiments were performed on ...
Electrophysiological recording of cultured hippocampal neurons The bath solution contained the following (in mM): 140 NaCl, 5 KCl, 2 MgCl2, 2 CaCl2, 10 HEPES, and 10 glucose, adjusted to pH 7.4 with NaOH. The whole-cell intracellular pipette solution contained the following (in mM): 126 Cs...
Currently, tetrodotoxin (TTX) is used solely as a research tool for studying voltage-dependent sodium channels, although there is interest in exploiting its effect on these channels in the treatment of pain. TTX-sensitive channels play an important role in the transmission of pain signals and ...
Given α2-ARs act through G-proteins, we examined the effect of GDPβ-s, a G protein inhibitor, on DEX-induced rapid suppression of Nav1.8 currents in small DRG neurons. Inclusion in pipette solution of GDPβ-s (1 mM) did not impair Nav1.8 activation. On the other hand, the inhibitio...
Tetrodotoxin-resistant action potentials in dorsal root ganglion neurons are blocked by local anesthetics. Pain 2000; 89: 47±52... SW Vogel - 《Pain》 被引量: 114发表: 2000年 The effects of halothane and isoflurane on slowly inactivating sodium current in canine cardiac Purkinje cells. ) ...
Effect of dexmedetomidine on excitability of DRG neurons Nav1.8 is the main contributor to the upstroke of action potentials in small-diameter DRG neurons [18]. Thus, modulation of this channel by DEX should influence the excitability of DRG neurons. We applied 10 ms step de- polarizing ...
网络释义 1. 河豚毒敏感性 与河豚毒敏感性 (Tetrodotoxin-sensitive) 的钠離子通道、钙離子依ir.ym.edu.tw|基于1 个网页 例句 释义: 全部,河豚毒敏感性 更多例句筛选 1. The effect of bupivacaine on tetrodotoxin-resistant and tetrodotoxin-sensitive sodium channels in rat dorsal root ganglion neurons ...
Because only a subset of neurons were positive for PN3 expression, PN3 mRNA could have been undetectable by RT-PCR assays using the entire spinal cord (dilution effect). Immunoprecipitation experiments indicated that PN3 expressing Chinese hamster lung (CHL) cells had a ˜250 kD protein which...
CONCLUSIONS We established a functional link between α2-AR and Nav1.8 in primary sensory neurons utilizing the Gi/o/AC/cAMP/PKA pathway, which probably mediating peripheral analgesia of DEX. 中文翻译: 右美托咪定通过大鼠背根神经节神经元的Gi / o依赖性途径抑制抗河豚毒素的Nav1.8钠通道活性。
Background Systemically administered dexmedetomidine (DEX), a selective α2 adrenergic receptor (α2-AR) agonists, produces analgesia and sedation. Peripherally restricted α2-AR antagonist could block the analgesic effect of systemic DEX on neurop