Carry out the test for sterility using 10 mLfor each medium.Absence of toxin and irreversibility of toxoid. Using the samebuffer solution as for the final vaccine, without adsorbent,prepare a solution of bulk purified toxoid at the sameconcentration as in the final vaccine. Divide the dilution ...
Tetanus toxoids (i.e. chemically inactivated preparations of tetanus neurotoxin) are used for the production of tetanus vaccines. In order to exclude the r... HA Behrensdorf-Nicol,U Bonifas,KM Hanschmann,... - 《Vaccine》 被引量: 6发表: 2013年 Ultrafiltration before detoxification enhance the...
Quantitative bioassay of adsorbed tetanus toxoids was performed in white mice using the score design of Ipsen. The precision, reproducibility and validity of the test were estimated and it was shown that the quantitative scored test has an advantage over the probit system. Mice were found to be...
发明人: HELTING, TORSTEN B., DR., MARBACH 摘要: An atoxic, immunogenic product obtained by treating tetanus toxin with a proteinase, a process for its manufacture and a tetanus vaccine containing as the essential ingredient said atoxic immunogenic product.收藏...
发明人: HELTING, TORSTEN B., DR., MARBACH 摘要: An atoxic, immunogenic product obtained by treating tetanus toxin with a proteinase, a process for its manufacture and a tetanus vaccine containing as the essential ingredient said atoxic immunogenic product.收藏...
This was made possible by the high sensitivity of the agglutination techniques whereby reliable antibody titers to three antigens, diphtheria and tetanus toxoids and pertussis vaccine, were obtained for each treatment group from single heel punctures. The methods were described and the evidence of ...
- 《Vaccine》 被引量: 12发表: 2013年 Safety and immunogenicity of Haemophilus influenzae type b-tetanus toxoid conjugate, presented in a dual-chamber syringe with diphtheria-tetanus-pertussis ... The safety and immunogenicity of combining two established vaccines, polyribosyl ribitol phosphate ...