白为Fe2+和0【一酮戊二酸(a—ketoglutarate,旺-KG)依赖 募集后在含半胱氨酸的天冬氨酸蛋白水解酶 性双加氧酶,可催化5一甲基胞嘧啶(5一methylcytosine, (caspsaes)参与下降解TET2蛋白,与上述猜测相 5-mC)羟甲基化为 5一羟甲基胞嘧啶 一致。 (5一hydroxymethylcytosine,5一hmC),进而调控DNA ...
SO far.As an alpha—ketoglutarate (a-KG)and Fe(II)一depe genome・ In this study to provide experimental evidence for the pathogenesis and prognosis of MDS,we examined the relationship between TET2 mutations and 5-hmC levels,the epigenetic effects of TET2 and 5-hmC on the methylation of ...
TET2is frequently affected by hypomorphic missense mutations and loss-of-function (LOF) nonsense/frameshift-truncating mutations1,2. TET2 is a Fe2+catalyzed 2-oxoglutarate (αKG) dependent DNA-dioxygenase that progressively oxidizes 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5...
A single dose of LPS (intraperitoneally [i.p.], 0.8 mg/kg) was administered to adult WT or Tet2-KO mice (∼3–4 months old). n = 4–10 mice per group; results are pooled from multiple experiments. (B) LPS induces aberrant emergency granulopoiesis in Tet2-KO mice, revealed by ...