With prostate cancer not observed in eunuchs and total androgen suppression by castration an effective first-line treatment for advanced prostate cancer, the dramatic regression seen in tumour symptoms after castration, lead to the theory that high levels of circulating androgens were a risk factor ...
Testosterone replacement therapy and risk of favorable and aggressive prostate cancer. J Clin Oncol. 2017;35:1430–6. Article Google Scholar Walsh TJ, Shores MM, Krakauer CA, Forsberg CW, Fox AE, Moore KP, et al. Testosterone treatment and the risk of aggressive prostate cancer in men with...
We identified 69,984 patients with localized prostate cancer diagnosed from 2001 to 2015 treated with surgery or radiation. We coded receipt of TT after treatment as a time-dependent covariate; used the National Death Index to identify cause of death; and defined biochemical recurrence as PSA>0.2...
The use of testosterone therapy in men with prostate cancer was previously contraindicated, although recent data challenge this axiom. Over the past 2 decades, there has been a dramatic paradigm shift in beliefs, attitude, and treatment of testosterone deficiency in men with...
Should hypogonadal men with prostate cancer receive testosterone? Yes O ffering testosterone (T) therapy to men with prostate cancer (PCa) flies in the face of all training and tradition. Yet there are good reasons to consider this therapy. Treatment of testosterone deficiency (TD) can successful...
A treatment paradox has recently come to light in prostate cancer: Blocking testosterone production halts tumor growth in early disease, while elevating the hormone can delay disease progression in patients whose disease has advanced. The inability to understand how different levels of the same hormone...
This phase IV trial studies the effects of testosterone replacement therapy (TRT) on treatment outcomes in hypogonadal men with prostate cancer that has not spread to other parts of the body (localized) and who are on active surveillance (AS). AS in prostate cancer involves closely watching the...
The overall goal of this investigation is to provide an effective long-term treatment strategy that prevents the advancement of COPD in men and women through a safe, cycled administration of testosterone during the early stages of disease. 显示全部 开始日期2021-12-01 申办/合作机构 University of ...
5085#Background:Patients (pts) with high-risk localized prostate cancer (HRLPC) have a significant risk of disease recurrence and metastasis after radical ... DA Bastos,R Coelho,L Cardili,... - 《Journal of Clinical Oncology》 被引量: 0发表: 2022年 Treatment situation of male hypogonadotrop...
Prostate biopsy revealed Gleason 6 cancer in both lobes. He refused treatment for PCa, but requested T therapy, which was initiated with T gel after informed consent regarding possible cancer progression. Serum T increased to a mean value of 699 ng/dL and free T to 17.1 pg/mL. PSA ...