Together, these observations suggest a functional link between CTCF and BORIS and other testis-specific TSTRs in the regulation of germ cell transcription. In support of this idea, we find that BORIS physically interacts with TATA-binding protein (TBP)-associated factor 7-like (TAF7L) in both ...
1 Remarkably, apart from stem cells, there was enrichment of several transcription factors which are known to be specific or have an important role in the testis, namely: TAF7L (TATA-Box-Binding Protein Associated Factor 7 Like), TBPL1 (TATA-Box-Binding Protein Like 1), ZFP384 (Zinc ...
CREB and CREM are factors directly coupled to signaling pathways. Phosphorylation within the P-box, and consequent CBP interaction, turns them into powerful activators1, 2. The activation domain (AD) comprises also two glutamine-rich regions Q1 and Q2 interaction to the TBP-associated hTAF130 see...
As a TBP-interacting transcriptional modulator, ZNF76 is also regulated by alternative splicing. 分子量 62 kDa 基因ID 7629 NCBI登录号 NP_003418, NM_003427 UniProt P36508 研究领域 Chromatin and Nuclear Signaling, Transcription Factors 使用细节 Zinc Finger Protein 76 (Expressed in Testis)...
Although apoptotic cell counts increased in 13-week cKO testis, numbers were still low (~1.2 apoptotic cells per tubule) and there was no preference for any specific cell type (Figure 4e). These results suggested that the testicular atrophy observed in cKO mice was not caused by induction of...