Experimental GerontologyScarabino, D.; Broggio, E.; Gambina, G.; Pelliccia, F.; Corbo, R.M. Common variants of human TERT and TERC genes and susceptibility to sporadic Alzheimers disease. Exp. Gerontol. 2017, 88, 19-24. [CrossRef] [PubMed]...
In most cancers, germline and stem cells, long-term proliferation requires telomerase activity to overcome the telomere shortening, which occurs with cell division. This shortening eventually arrests cellular growth, potentially providing an initial proliferative barrier to tumor formation in humans [5]. ...
Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat. Genet. 40, 1407–1409 (2008). Article CAS PubMed PubMed Central Google Scholar Johnatty, S.E. et al. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer ...
Idiopathic pulmonary fibrosis (IPF) was considered as a telomere-mediated disease. TERT and TERC correlated with telomere length. Although telomerase gene mutations were associated with IPF, majority patients did not carry mutations. The mechanism by whi
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Recent work has suggested that chromosomal abnormalities encompassing the genes driving proliferation, including gain of chromosome 7 where EGFR and PDGFA reside, precede TERTp mutations in GBM and that TERTp mutations are necessary for clonal expansion (Körber et al., 2019). The early placement...
(n= 37,684 individuals)1. Alleles associated with glioma risk nearTERCandTERTwere strongly associated with longer LTL (P= 5.5 × 10−20and 4.4 × 10−19, respectively). In contrast, risk-associated alleles nearRTEL1were inconsistently associated with LTL, suggesting the presence of distinct...
MNS16A is a minisatellite located downstream of exon 16 of the TERT gene.The L allele of this polymorphism is associated reduced the expression ofTERT.The LL and LS genotypes significantly higher in heroin dependents compared with controls.The age of first use of drug was lower in the LL and...
This genomic region contains two plausible candidate genes, TERT and CLPTM1L. The former encodes the catalytic subunit of the telomerase reverse transcriptase (TERT), which in combination with an RNA template (TERC) adds nucleotide repeats to chromosome ends19. Although telomerase is active in ...
mRNA levels of the indicated genes were quantified by qRT-PCR (a, b). Mitochondrial superoxide production was measured by MitoSox Red fluorescence (c, d) and expressed as fluorescence relative to vector or DMSO controls. e NRASmut melanoma cells were treated with 1 µM of 6-thio-dG ...