Hou (Cancer Institute, Xuzhou Medical University, China). The DNA fragment of UPCP was inserted into the vector pET28a(+). Human BUBR1 shRNAs were cloned into pLKO.1 plasmid (pLKO.1-BUBR1#1 and pLKO.1-BUBR1#3). The sequences of shRNAs are described below: shCtrl_fwd (5′-CCGGA...
Jones has a genetic disposition for a rare terminal strain of cancer which should ideally cause him to expire within 40 months of the project's inception. These two events should combine to allow a proper catalyst that allows this project to continue as planned. ...
6B). We took advantage of the patient-derived xenograft system to explore the effect of BET inhibition on MYC expression in CAFs in vivo. The pathological structure of the xenograft tissues mimics the primary cancer tissues and the tumor stroma is obvious and easily identified in PDX. ...
Metastasis is the primary cause of death for cancer patients. TWIST1, an evolutionarily conserved basic helix-loop-helix (bHLH) transcription factor, is a strong promoter of metastatic spread and its expression is elevated in many advanced human carcinomas. However, the molecular events triggered by...
Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer. Front. Oncol. 2021, 10, 592501. [Google Scholar] [CrossRef] [PubMed] Sharma, A.; Liu, H.; Tobar-Tosse, F.; Chand Dakal, T.; Ludwig, M.; Holz, ...
Metastasis is the primary cause of death for cancer patients. TWIST1, an evolutionarily conserved basic helix-loop-helix (bHLH) transcription factor, is a strong promoter of metastatic spread and its expression is elevated in many advanced human carcinomas. However, the molecular events triggered by...