Treatment-related TEAEs were tolerable; the most common was dizziness (Study 231, 53.3%; Study 233, 14.3%). Mean perampanel plasma concentrations were lower with concomitant carbamazepine vs non-inducers (152.7ng/mL vs 389.4ng/mL across perampanel groups); small patient numbers for non-inducers ...
I've had the ability to rent movies on demand for YEARS on Comcast Cable, and they have had HD movies for two years. They aren't portable (see below) but certainly I can sit down and watch a movie instantly unless I'm too lazy to walk to the video store. The Xbox360 also has O...
Metaplasia is a transformation of one differentiated cell type to another related type not normally present in a specific tissue.47,48 It is the result of an altered gene expression in response to, for example, chronic physiologic, chemical, or physical irritation.48, 49, 50, 51 The resulting...
Colorectal cancer (CRC) stands as the third leading cause of global cancer-related mortality [1], and its incidence is higher in people related to obesity, physical inactivity, or alcohol consumption and is increasing in younger patients (≤50 years) [2]. Approximately 20% of newly diagnosed ...
outcomes in adolescents and young adult patients treated with pediatric regimens led us to initiate a clinical trial to determine whether an intensive pediatric ALL chemotherapy protocol for children o18 years old would be tolerable for 18–50- year-old adults and would result in improved outcomes....
I like to drink. Things happen and I laugh a lot. Even the hangovers are tolerable, and I invariably go to the gym the day after,ifI have a scheduled workout (I train every second day, year in, year out). Still, it’s kind of bad in the mid-term (hangover) and quite bad in...
Treatment-related AEs leading to dose modification (or interruption) or to discontinuation were observed in 5 (5%) and 1 (1%) patients, respectively. Atezolizumab was also tolerable in patients 65 years or older (eTable 2 in Supplement 2). Adverse events of special interest regardless of ...
And so, we have to think about patients’ risk of infection. We know that there are long-term consequences for being on steroids, especially at higher doses and for longer periods of time. And so, this sort of list here kind of goes through a lot of these things that we think about...
In this 6-month, multicenter, open-label safety study — during which study medication was used to treat more than 2000 migraine attacks — DFN-02 was safe and tolerable for the acute treatment of patients with episodic migraine with and without aura. Adverse events with DFN-02 were similar ...
According to some studies, docetaxel and cisplatin chemotherapy administered concurrently with radiotherapy was highly effective in treating unresectable localized ESCC with tolerable toxicities, which has been hailed as promising [16, 17]. Therefore, in order to provide strong evidence for the efficacy ...